Document Detail

Change in blood pressure during altered sodium intake is not associated with calciotropic hormone level.
MedLine Citation:
PMID:  9301430     Owner:  NLM     Status:  MEDLINE    
1. We evaluated the effects of the dietary restriction of sodium chloride on blood pressure and systemic calcium metabolism in 19 in-patients with essential hypertension (11 men and 8 women, mean age 49.9 +/- 12.1 years). 2. All patients received a high-sodium diet (250 mmol/day) for 1 week, followed by a low-sodium diet (10 mmol/day) for another week. Intake of potassium (100 mmol/day) and of calcium (15 mmol/day) were kept constant throughout the study. 3. Sodium restriction significantly reduced the mean blood pressure (from 114.0 +/- 1.9 to 105.0 +/- 13.7 mmHg, P < 0.01). Urinary calcium excretion was significantly reduced (from 5.1 +/- 2.4 to 2.2 +/- 1.0 mmol/day, P < 0.01). 4. The change in mean blood pressure after sodium restriction was not correlated with a change in any parameter of calcium metabolism [whole blood ionized calcium, plasma intact parathyroid hormone, or 1,25-(OH)2 vitamin D3]. 5. Plasma renin activity during a regular sodium diet, an index of renin status, was significantly and inversely correlated with the change in blood pressure during sodium restriction, but not with any change in the parameters of calcium metabolism. 6. We conclude that sodium restriction reduces blood pressure and decreases urinary calcium excretion. However, we observed no significant role of extracellular calcium concentration or of calciotropic hormone concentration in the mechanism of sodium sensitivity.
R Ozono; T Oshima; H Matsuura; K Ishibashi; M Watanabe; M Yoshimura; G Kajiyama; M Kambe
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  93     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-15     Completed Date:  1997-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Blood Pressure / physiology*
Calcitriol / blood
Calcium / blood,  metabolism*,  urine
Middle Aged
Parathyroid Hormone / blood
Renin / blood
Sodium Chloride, Dietary / administration & dosage*
Reg. No./Substance:
0/Parathyroid Hormone; 0/Sodium Chloride, Dietary; 32222-06-3/Calcitriol; 7440-70-2/Calcium; EC

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