Document Detail


Change in blood lead concentration up to 1 year after a gunshot wound with a retained bullet.
MedLine Citation:
PMID:  15033646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors studied the time course and prevalence of elevated blood lead concentrations and associated injury- and patient-specific factors during the first year following gunshot injury. They determined blood lead levels at mean time points of 0.3, 3.1, 18.7, 94.5, 188.3, and 349.4 days after injury in a volunteer sample of 451 subjects from a Los Angeles, California, trauma center who sustained a first-time gunshot injury with a retained projectile in 2000-2002. In mixed-model analyses, blood lead levels increased with time postinjury (p < 0.0005) up to 3 months, with number of retained fragments (p < 0.0005), and with increasing age (p < 0.0005). Increased blood lead concentration as a function of fragmentation was approximately 30% higher among subjects who had suffered bone fracture in the torso (p < 0.0005). Subjects with bullets or fragments lodged near bone (p < 0.0005) or near joints (p = 0.032) had higher blood lead levels. Logistic models correctly predicted a blood lead elevation of >/=20 micro g/dl in 81% and 85% of subjects at 3 and 6 months postinjury, respectively. The prevalence of elevated blood lead was 11.8% at 3 months and 2.6% at 12 months. The authors recommend continued surveillance of blood lead levels after gunshot injury for patients with key indicators.
Authors:
Joseph L McQuirter; Stephen J Rothenberg; Gracie A Dinkins; Vladislav Kondrashov; Mario Manalo; Andrew C Todd
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  159     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-22     Completed Date:  2004-04-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  683-92     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Body Burden
Calcaneus / metabolism
Child
Female
Follow-Up Studies
Foreign Bodies / blood*,  complications*
Humans
Lead / blood*
Lead Poisoning / etiology*
Male
Middle Aged
Prospective Studies
Tibia / metabolism
Time Factors
Wounds, Gunshot / blood*
Grant Support
ID/Acronym/Agency:
ES10166/ES/NIEHS NIH HHS; RR03026/RR/NCRR NIH HHS; RR11145/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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