| Change in use of gadolinium-enhanced magnetic resonance studies in kidney disease patients after US Food and Drug Administration warnings: a cross-sectional study of Veterans Affairs Health Care System data from 2005-2008. | |
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MedLine Citation:
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PMID: 20580477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Exposure to gadolinium in patients with kidney disease has been linked to risk of developing nephrogenic systemic fibrosis. The US Food and Drug Administration (FDA) has issued warnings against the use of gadolinium in this population. We studied the impact of these warnings on the use of gadolinium-enhanced magnetic resonance (GE-MR) studies in patients with decreased estimated glomerular filtration rate (eGFR) and the practice of measuring serum creatinine before gadolinium exposure. STUDY DESIGN: Cross-sectional study of patients who had undergone MR studies from October 2002 to September 2008. SETTING & PARTICIPANTS: Patients receiving medical care in the US Department of Veterans Affairs Health Care System. PREDICTOR: Date of MR imaging, serum creatinine level, and eGFR using the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation. OUTCOMES & MEASUREMENTS: The rate of MR studies performed with and without gadolinium from July 2005 to September 2008 in patients with different stages of kidney disease, defined using eGFR. The proportion of GE-MR studies with a screening serum creatinine level. RESULTS: There was a 71% decrease in the rate of GE-MR use in patients with GFR<30 mL/min/1.73 m2 2 years after the release of the first public health advisory, although studies continued to be performed in patients with stages 4 and 5 chronic kidney disease. The proportion of GE-MR studies with serum creatinine measured within 1 month before the study increased by 99%. LIMITATIONS: Data available up to September 30, 2008. Indications for the GE-MR studies were not assessed. The accuracy of Current Procedural Terminology and International Classification of Diseases, Ninth Revision coding was not assessed. CONCLUSION: There was a large decrease in the use of GE-MR studies in patients with GFR<30 mL/min/1.73 m2 and a large but not universal increase in the practice of measuring serum creatinine before GE-MR after the release of the FDA warnings. |
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Authors:
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Kyung-Ho Kim; Jennifer R Fonda; Elizabeth V Lawler; David Gagnon; James S Kaufman |
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Publication Detail:
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Type: Journal Article Date: 2010-06-26 |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 56 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 458-67 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 National Kidney Foundation, Inc. All rights reserved. |
Affiliation:
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Renal Section, State University of New York at Stony Brook, Stony Brook, NY 11794, USA. kykkim@notes.cc.sunysb.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Adverse Drug Reaction Reporting Systems* Aged Aged, 80 and over Contrast Media* / adverse effects Creatinine / blood Cross-Sectional Studies Databases, Factual Drug Utilization / statistics & numerical data Female Gadolinium* / adverse effects Glomerular Filtration Rate Guideline Adherence / statistics & numerical data* Humans Kidney Diseases* / blood, physiopathology Magnetic Resonance Imaging* Male Middle Aged United States United States Department of Veterans Affairs United States Food and Drug Administration* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 60-27-5/Creatinine; 7440-54-2/Gadolinium |
| Comments/Corrections | |
Comment In:
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Am J Kidney Dis. 2010 Sep;56(3):427-30
[PMID:
20728788
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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