| Change in 25-hydroxyvitamin D and physical performance in older adults. | |
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MedLine Citation:
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PMID: 21325343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin D deficiency is common among older adults and is associated with poor physical performance; however, studies examining longitudinal changes in 25-hydroxyvitamin D (25[OH]D) and physical performance are lacking. We examined the association between 25(OH)D and physical performance over 12 months in older adults participating in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P), a multicenter physical activity intervention trial. METHODS: Plasma 25(OH)D and physical performance, assessed by the short physical performance battery (SPPB) and 400-m walk test, were measured at baseline, 6-month, and 12-month follow-up in community-dwelling adults aged 70-89 years at risk for disability (n = 368). Mixed models were used to examine the association between 25(OH)D and physical performance adjusting for demographics, intervention group, season, body mass index, and physical activity. RESULTS: One half of the participants were vitamin D deficient (25[OH]D < 20 ng/mL) at baseline. In cross-sectional analyses, vitamin D deficiency was associated with lower SPPB scores and slower 400-m walk speeds (mean difference [SE]: 0.35 [0.16], p = .03 and 0.04 [0.02] m/s, p = .01, respectively). Although baseline 25(OH)D status was not significantly associated with change in physical performance over 12 months, individuals who were vitamin D deficient at baseline but no longer deficient at follow-up had significant improvements in SPPB scores (mean difference [SE]: 0.55 [0.22], p = .01) compared with those whose 25(OH)D status remained the same. CONCLUSION: Increases in 25(OH)D to greater than or equal to 20 ng/mL were associated with clinically significant improvements in physical performance among older adults. |
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Authors:
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Denise K Houston; Janet A Tooze; Dorothy B Hausman; Mary Ann Johnson; Barbara J Nicklas; Michael E Miller; Rebecca H Neiberg; Anthony P Marsh; Anne B Newman; Steven N Blair; Stephen B Kritchevsky |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2011-02-16 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 66 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-06-02 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 430-6 Citation Subset: AIM; IM |
Affiliation:
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Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157-1207, USA. dhouston@wfubmc.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00116194 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cross-Sectional Studies Exercise* Female Humans Male Multicenter Studies as Topic Randomized Controlled Trials as Topic Vitamin D / analogs & derivatives*, blood Vitamin D Deficiency / therapy* |
| Grant Support | |
ID/Acronym/Agency:
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K01 AG030506/AG/NIA NIH HHS; K01 AG030506-04/AG/NIA NIH HHS; P30 AG21332/AG/NIA NIH HHS; U01 AG22376/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
| Comments/Corrections | |
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