Document Detail

Change of Plasma Osteoprotegerin and its Association with Endothelial Dysfunction before and after Exercise in Hashimoto's Thyroiditis with Euthyroidism.
MedLine Citation:
PMID:  23070830     Owner:  NLM     Status:  In-Data-Review    
Osteoprotegerin (OPG) is a recently identified inhibitor of bone resorption. Recent studies indicated that OPG also acts as an important regulatory molecule in the vasculature. The purpose of this study was to investigate the change of OPG and its associations with endothelial function before and after exercise training in Hashimoto's thyroiditis (HT) with euthyroidism.The study subjects included 62 newly diagnosed sedentary Chinese Han HT women with euthyroidism and 28 sedentary Chinese Han female healthy subjects. All individuals participated in an exercise training of 6 months. Plasma OPG concentrations were measured in duplicate by a sandwich enzyme-linked immunosorbent assay, and high resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia, and after sublingual glyceryltrinitrate.The OPG concentration in HT patients with euthyroidism before exercise was 3.0±0.81 ng/L, which was significantly higher than that in control subjects (2.44±0.24 ng/L, p<0.001). After 6 months of exercise, OPG levels decreased markedly (2.40±0.61 ng/L, p<0.001). Flow-mediated dilation (FMD) in HT patients with euthyroidism before exercise was 4.06±0.78%, which was significantly lower than that in control subjects (5.54±0.61%, p<0.001), and it improved markedly after 6 months of exercise (5.0±0.79, p<0.001). The absolute changes in OPG showed significant correlation with the changes in FMD (r= - 0.432, p=0.001), TBARS (r= - 0.370, p=0.004) and CRP (r= - 0.503, p<0.001).The current study demonstrates that plasma OPG levels increased significantly at baseline, decreased dramatically after 6 months regular aerobic exercise training, and are correlated with endothelium-dependent arterial dilation in HT patients with euthyroidism. Clinical Trial Registration Number: No.
G Xiang; L Xiang; L Xiang; H Wang; J Dong
Publication Detail:
Type:  Journal Article     Date:  2012-10-15
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  120     ISSN:  1439-3646     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  529-34     Citation Subset:  IM    
Copyright Information:
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, Hubei Province, P. R. China.
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