| The Change of Plasma Ghrelin and Leptin Levels by the Development of Type 2 Diabetes Mellitus in Patients With Alcohol Dependence. | |
| | |
MedLine Citation:
|
PMID: 21294754 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: There have been lots of studies about the relationship between chronic use of alcohol and the development of type 2 diabetes mellitus (T2DM). Chronic use of alcohol can be affected by the altered level of ghrelin and leptin which regulate food-seeking behavior having similar mechanism of controlling alcohol-craving behavior. Those peptides are known to be correlated with T2DM. Ghrelin and leptin also have been regarded as possible regulators of glucose metabolism and insulin function. Hence, there is the possibility that ghrelin and leptin can be related with deteriorated pathophysiology of T2DM in alcoholic patients. Methods: Patients with alcohol dependence diagnosed by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) underwent an 75 g oral glucose-tolerance test (OGTT), to classify them to normal glucose tolerance (NGT, n = 52), pre-diabetes including impaired glucose tolerance (IGT), impaired fasting glucose level (IFG) and combination of IGT and IFG (Pre-DM, n = 26) and T2DM (n = 24) groups. Fasting plasma ghrelin and leptin levels were compared among groups. Results: There was no difference of ghrelin concentration among the groups but the leptin concentration was significantly different between NGT and T2DM group (p < 0.05). Increased leptin levels were significantly correlated with body mass index (BMI), insulin level, and insulin resistance. Conclusions: Chronic alcohol drinking might produce leptin resistance which makes leptin significantly correlated with fasting insulin concentration and insulin resistance. Therefore, we suppose that increased level of leptin by chronic alcohol use could be one of the main mechanisms that develop insulin resistance in alcoholic patients. |
| | |
Authors:
|
Anes Ju; Young-Hoon Cheon; Kye-Seong Lee; Seong-Su Lee; Won-Young Lee; Wang-Youn Won; Sang-Ick Park; Won-Ho Kim; Dai-Jin Kim |
Related Documents
:
|
18357774 - The cvb and etiology of type 1 diabetes. 8314024 - Beta 2-microglobulin-deficient nod mice do not develop insulitis or diabetes. 11756344 - Congenic mapping of the diabetogenic locus idd4 to a 5.2-cm region of chromosome 11 in ... 8864824 - Induction of diabetes in nod<-->c57bl/6 embryo aggregation chimeras by cyclophosphamide... 8593934 - Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle o... 16303834 - The metabolic syndrome is associated with reduced central serotonergic responsivity in ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-5 |
Journal Detail:
|
Title: Alcoholism, clinical and experimental research Volume: - ISSN: 1530-0277 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 by the Research Society on Alcoholism. |
Affiliation:
|
From the Department of Biomedical Science (AJ, DJK), The Catholic University of Korea College of Medicine, Seoul, South Korea; Department of Psychiatry (YHC), Incheon Chamsarang Hospital, Seojin Medical Research Institute, Incheon, South Korea; Department of Psychiatry (KSL), Addiction Center, Seoul National Hospital, An affiliate of Ministry for Health, Welfare & Family Affairs, Seoul, South Korea; Division of Endocrinology and Metabolism (SSL), Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, South Korea; Division of Endocrinology and Metabolism (WYL), Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Psychiatry (WYW, DJK), Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea; and Division of Intractable Diseases (SIP, WHK), Center for Biomedical Sciences, National Institutes of Health in Korea (KNIH), Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Moderate prenatal alcohol exposure and serotonin genotype interact to alter CNS serotonin function i...
Next Document: Leptin and Acetaldehyde Synergistically Promotes ?SMA Expression in Hepatic Stellate Cells by an Int...