| The Change of Functional Connectivity Specificity in Rats Under Various Anesthesia Levels and its Neural Origin. | |
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MedLine Citation:
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PMID: 23208517 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Spatiotemporal correlations of spontaneous blood oxygenation level dependent (BOLD) signals measured in the resting brain have been found to imply many resting-state coherent networks under both awake/conscious and anesthetized/unconscious conditions. To understand the resting-state brain networks in the unconscious state, spontaneous BOLD signals from the rat sensorimotor cortex were studied across a wide range of anesthesia levels induced by isoflurane. Distinct resting-state networks covering functionally specific sub-regions of the sensorimotor system were observed under light anesthesia with 1.0 % isoflurane; however, they gradually merged into a highly synchronized and spatially less-specific network under deep anesthesia with 1.8 % isoflurane. The EEG power correlations recorded using three electrodes from a separate group of rats showed similar dependency on anesthesia depth, suggesting the neural origin of the change in functional connectivity specificity. The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states. |
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Authors:
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Xiao Liu; Xiao-Hong Zhu; Yi Zhang; Wei Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-4 |
Journal Detail:
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Title: Brain topography Volume: - ISSN: 1573-6792 ISO Abbreviation: Brain Topogr Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8903034 Medline TA: Brain Topogr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, 2021 6th St. SE, Minneapoli, MN, 55455, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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