Document Detail


The change of functional connectivity specificity in rats under various anesthesia levels and its neural origin.
MedLine Citation:
PMID:  23208517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spatiotemporal correlations of spontaneous blood oxygenation level dependent (BOLD) signals measured in the resting brain have been found to imply many resting-state coherent networks under both awake/conscious and anesthetized/unconscious conditions. To understand the resting-state brain networks in the unconscious state, spontaneous BOLD signals from the rat sensorimotor cortex were studied across a wide range of anesthesia levels induced by isoflurane. Distinct resting-state networks covering functionally specific sub-regions of the sensorimotor system were observed under light anesthesia with 1.0% isoflurane; however, they gradually merged into a highly synchronized and spatially less-specific network under deep anesthesia with 1.8% isoflurane. The EEG power correlations recorded using three electrodes from a separate group of rats showed similar dependency on anesthesia depth, suggesting the neural origin of the change in functional connectivity specificity. The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states.
Authors:
Xiao Liu; Xiao-Hong Zhu; Yi Zhang; Wei Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-04
Journal Detail:
Title:  Brain topography     Volume:  26     ISSN:  1573-6792     ISO Abbreviation:  Brain Topogr     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2014-01-23     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8903034     Medline TA:  Brain Topogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-77     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / pharmacology*
Animals
Blood Pressure / drug effects
Brain / blood supply,  drug effects*
Brain Mapping*
Brain Waves / drug effects*,  physiology
Dose-Response Relationship, Drug
Electroencephalography
Functional Laterality
Image Processing, Computer-Assisted
Isoflurane / pharmacology*
Magnetic Resonance Imaging
Neural Pathways / blood supply,  drug effects
Oxygen / blood
Rats
Rats, Sprague-Dawley
Regression Analysis
Grant Support
ID/Acronym/Agency:
NS041262/NS/NINDS NIH HHS; NS041262S1/NS/NINDS NIH HHS; NS057560/NS/NINDS NIH HHS; NS070839/NS/NINDS NIH HHS; P30 NS057091/NS/NINDS NIH HHS; P30 NS076408/NS/NINDS NIH HHS; P30NS057091/NS/NINDS NIH HHS; P30NS076408/NS/NINDS NIH HHS; P41 EB015894/EB/NIBIB NIH HHS; P41 EB015894/EB/NIBIB NIH HHS; P41 RR008079/RR/NCRR NIH HHS; P41 RR08079/RR/NCRR NIH HHS; R01 EB006433/EB/NIBIB NIH HHS; R01 NS041262/NS/NINDS NIH HHS; R01 NS057560/NS/NINDS NIH HHS; R01 NS070839/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; CYS9AKD70P/Isoflurane; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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