Document Detail


Chance and necessity do not explain the origin of life.
MedLine Citation:
PMID:  15563395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Where and how did the complex genetic instruction set programmed into DNA come into existence? The genetic set may have arisen elsewhere and was transported to the Earth. If not, it arose on the Earth, and became the genetic code in a previous lifeless, physical-chemical world. Even if RNA or DNA were inserted into a lifeless world, they would not contain any genetic instructions unless each nucleotide selection in the sequence was programmed for function. Even then, a predetermined communication system would have had to be in place for any message to be understood at the destination. Transcription and translation would not necessarily have been needed in an RNA world. Ribozymes could have accomplished some of the simpler functions of current protein enzymes. Templating of single RNA strands followed by retemplating back to a sense strand could have occurred. But this process does not explain the derivation of "sense" in any strand. "Sense" means algorithmic function achieved through sequences of certain decision-node switch-settings. These particular primary structures determine secondary and tertiary structures. Each sequence determines minimum-free-energy folding propensities, binding site specificity, and function. Minimal metabolism would be needed for cells to be capable of growth and division. All known metabolism is cybernetic--that is, it is programmatically and algorithmically organized and controlled.
Authors:
J T Trevors; D L Abel
Related Documents :
8649985 - Lack of biological significance in the 'linguistic features' of noncoding dna--a quanti...
21959055 - Renal and glycemic effects of high-dose chromium picolinate in db/db mice: assessment o...
23497475 - A permissive chromatin structure is adopted prior to site-specific dna demethylation of...
10877475 - Neural networks predict protein folding and structure: artificial intelligence faces bi...
25344215 - Redox cycling of cu(ii) by 6-mercaptopurine leads to ros generation and dna breakage: p...
21858215 - Systematic spatial bias in dna microarray hybridization is caused by probe spot positio...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell biology international     Volume:  28     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-25     Completed Date:  2005-04-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  729-39     Citation Subset:  IM    
Affiliation:
Laboratory of Microbial Technology, Department of Environmental Biology, Room 3220, Bovey Building, University of Guelph, Guelph, Ontario, Canada, N1G 2W1. jtrevors@uoguelph.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biogenesis*
DNA / genetics
Evolution, Molecular*
Genetic Code*
Humans
Proteins / genetics
RNA / genetics
Selection, Genetic*
Chemical
Reg. No./Substance:
0/Proteins; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Simple bone cysts of the calcaneus: a report of five cases and a review of the literature.
Next Document:  Kinetics of Smac/DIABLO release from mitochondria during apoptosis of MCF-7 breast cancer cells.