Document Detail

Chance and necessity do not explain the origin of life.
MedLine Citation:
PMID:  15563395     Owner:  NLM     Status:  MEDLINE    
Where and how did the complex genetic instruction set programmed into DNA come into existence? The genetic set may have arisen elsewhere and was transported to the Earth. If not, it arose on the Earth, and became the genetic code in a previous lifeless, physical-chemical world. Even if RNA or DNA were inserted into a lifeless world, they would not contain any genetic instructions unless each nucleotide selection in the sequence was programmed for function. Even then, a predetermined communication system would have had to be in place for any message to be understood at the destination. Transcription and translation would not necessarily have been needed in an RNA world. Ribozymes could have accomplished some of the simpler functions of current protein enzymes. Templating of single RNA strands followed by retemplating back to a sense strand could have occurred. But this process does not explain the derivation of "sense" in any strand. "Sense" means algorithmic function achieved through sequences of certain decision-node switch-settings. These particular primary structures determine secondary and tertiary structures. Each sequence determines minimum-free-energy folding propensities, binding site specificity, and function. Minimal metabolism would be needed for cells to be capable of growth and division. All known metabolism is cybernetic--that is, it is programmatically and algorithmically organized and controlled.
J T Trevors; D L Abel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell biology international     Volume:  28     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-25     Completed Date:  2005-04-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  729-39     Citation Subset:  IM    
Laboratory of Microbial Technology, Department of Environmental Biology, Room 3220, Bovey Building, University of Guelph, Guelph, Ontario, Canada, N1G 2W1.
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MeSH Terms
DNA / genetics
Evolution, Molecular*
Genetic Code*
Proteins / genetics
RNA / genetics
Selection, Genetic*
Reg. No./Substance:
0/Proteins; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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