Document Detail


Challenges to maternal wellbeing during pregnancy impact temperament, attention, and neuromotor responses in the infant rhesus monkey.
MedLine Citation:
PMID:  20882585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relative maturity, alertness, and reactivity of an infant at birth are sensitive indices of the neonate's health, the quality of the pregnancy, and the mother's wellbeing. Even when fetal growth and gestation length have been normal, the maturing fetus can still be adversely impacted by both physical events and psychological challenges to the mother during the prenatal period. The following research evaluated 413 rhesus monkeys from 7 different types of pregnancies to determine which conditions significantly influenced the behavioral responsiveness and state of the young infant. A standardized test battery modeled after the Neonatal Behavioral Assessment Scale for human newborns was employed. The largest impairments in orientation and increases in infant emotional reactivity were seen when female monkeys drank alcohol, even though consumed at only moderate levels during part of the pregnancy. The infants' ability to focus and attend to visual and auditory cues was also affected when the gravid female's adrenal hormones were transiently elevated for 2 weeks by ACTH administration. In addition, responses to tactile and vestibular stimulation were altered by both this ACTH treatment and psychological disturbance during gestation. Conversely, a 2-day course of antenatal corticosteroids 1 month before term resulted in infants with lower motor activity and reactivity. These findings highlight several pregnancy conditions that can affect a young infant's neurobehavioral status, even when otherwise healthy, and demonstrate that alterations or deficits are specific to the type of insult experienced by the mother and fetus.
Authors:
Christopher L Coe; Gabriele R Lubach; Heather R Crispen; Elizabeth A Shirtcliff; Mary L Schneider
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Developmental psychobiology     Volume:  52     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-02-18     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-37     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Affiliation:
Harlow Center for Biological Psychology, University of Wisconsin, Madison, 53715, USA. ccoe@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods
Adrenal Cortex Hormones / administration & dosage
Adrenocorticotropic Hormone / administration & dosage
Animals
Animals, Newborn
Attention*
Auditory Perception
Cues
Ethanol / administration & dosage
Female
Macaca mulatta
Male
Maternal Behavior / psychology*
Motor Activity*
Neuropsychological Tests
Photic Stimulation / methods
Pregnancy
Prenatal Exposure Delayed Effects / psychology*
Temperament*
Visual Perception
Grant Support
ID/Acronym/Agency:
AA10079/AA/NIAAA NIH HHS; AA12277/AA/NIAAA NIH HHS; AI067518/AI/NIAID NIH HHS; HD057064/HD/NICHD NIH HHS; HD39386/HD/NICHD NIH HHS; K01 MH077687-05/MH/NIMH NIH HHS; KO1 MH077687/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 64-17-5/Ethanol; 9002-60-2/Adrenocorticotropic Hormone
Comments/Corrections

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