Document Detail

Challenges to conducting multicenter clinical research: ten points to consider.
MedLine Citation:
PMID:  18560285     Owner:  NLM     Status:  MEDLINE    
Nursing care provided to patients and their families should be based on strong scientific evidence. In the quantitative research paradigm, the highest level of evidence is derived from conclusive randomized controlled clinical trials. Multicenter clinical research allows the accrual of sufficient numbers of diverse participants in a shorter period of time and improves the generalizability of the study findings. Clinical research is inherently complex; the complexity exponentially increases when conducting multicenter clinical trials. Investigators are challenged to maintain the internal validity of the study and the sustained commitment and collaboration of numerous disciplines over the study period. This article presents 10 essential points to consider when conducting multicenter clinical research.
Sharon Y Irving; Martha A Q Curley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AACN advanced critical care     Volume:  19     ISSN:  1559-7768     ISO Abbreviation:  -     Publication Date:    2008 Apr-Jun
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101269322     Medline TA:  AACN Adv Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-9     Citation Subset:  N    
School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Biomedical Research*
Cooperative Behavior
Multicenter Studies as Topic
Patient Care Team
Pilot Projects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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