Document Detail

Challenges and pitfalls in prenatal screening in pregnancies involving allogeneic stem cell transplantation recipients.
MedLine Citation:
PMID:  17310136     Owner:  NLM     Status:  MEDLINE    
Increasing numbers of successful pregnancies are reported in recipients of allogeneic hemopoietic stem cell transplantation (HSCT). These may occur naturally, or more commonly, through assisted reproduction. The pregnancy outcomes are usually normal. There are currently no guidelines on the prenatal management of pregnancies involving HSCT recipients. HSCT recipients are unique in that their red cells, lymphocytes and even the DNA in the circulation are donor derived. As a result, typical prenatal screening tests in parents, including mean cell volume (MCV), hemoglobin pattern, blood group, infective serology and DNA screening, are all affected. The MCV cannot be used as guide for iron and folate supplements, or for thalassemia and sickle cell anemia screening. Such screening must be based on pre-HSCT indices and pre-HSCT DNA samples. The risks for hemolytic disease of newborn and hepatitis B virus transmission have to be re-evaluated, based on both pre- and post-HSCT patient as well as donor blood group and serology results. Good communication between obstetricians and the HSCT physician is paramount to promote successful pregnancies in this distinct patient population.
W Y Au; W C Leung
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-02-19
Journal Detail:
Title:  Bone marrow transplantation     Volume:  39     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-21     Completed Date:  2007-05-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  379-82     Citation Subset:  IM    
Bone Marrow Transplant Unit, Department of Medicine, Queen Mary Hospital, Hong Kong.
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MeSH Terms
Hematology / methods
Hematopoietic Stem Cell Transplantation / adverse effects,  methods*
Pregnancy Complications* / etiology
Pregnancy Outcome
Prenatal Care / methods*
Transplantation, Homologous / methods*
Virus Diseases / complications,  prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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