Document Detail

Challenges in testing genetically modified crops for potential increases in endogenous allergen expression for safety.
MedLine Citation:
PMID:  23205714     Owner:  NLM     Status:  Publisher    
Premarket, genetically modified (GM) plants are assessed for potential risks of food allergy. The major risk would be transfer of a gene encoding an allergen or protein nearly identical to an allergen into a different food source, which can be assessed by specific serum testing. The potential that a newly expressed protein might become an allergen is evaluated based on resistance to digestion in pepsin and abundance in food fractions. If the modified plant is a common allergenic source (e.g. soybean), regulatory guidelines suggest testing for increases in the expression of endogenous allergens. Some regulators request evaluating endogenous allergens for rarely allergenic plants (e.g. maize and rice). Since allergic individuals must avoid foods containing their allergen (e.g. peanut, soybean, maize, or rice), the relevance of the tests is unclear. Furthermore, no acceptance criteria are established and little is known about the natural variation in allergen concentrations in these crops. Our results demonstrate a 15-fold difference in the major maize allergen, lipid transfer protein between nine varieties, and complex variation in IgE binding to various soybean varieties. We question the value of evaluating endogenous allergens in GM plants unless the intent of the modification was production of a hypoallergenic crop.
R Panda; H Ariyarathna; P Amnuaycheewa; A Tetteh; S N Pramod; S L Taylor; B K Ballmer-Weber; R E Goodman
Related Documents :
24318944 - Nutritional correlates of the "lean season": effects of seasonality and frugivory on th...
24072544 - Survey on food hygiene knowledge on board ships.
22931854 - Food-induced brain responses and eating behaviour.
23601394 - Pacific tracker 2 - expert system (pactrac2-es) behavioural assessment and intervention...
18580944 - The borealis basin and the origin of the martian crustal dichotomy.
23701864 - Effect of nutritional factors on adherence to antiretroviral therapy among hiv-infected...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Allergy     Volume:  -     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Food Allergy Research and Resource Program, University of Nebraska, Lincoln, NE, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hydration and Aggregation in Mono- and Disaccharide Aqueous Solutions by GHz-to-THz Light Scattering...
Next Document:  A soluble granulocyte colony stimulating factor decoy receptor as a novel tool to increase hematopoi...