Document Detail

Challenges in the early diagnosis and staging of Fallopian-tube carcinomas associated with BRCA mutations.
MedLine Citation:
PMID:  12649664     Owner:  NLM     Status:  MEDLINE    
The histopathologic diagnosis of fallopian-tube carcinoma has been traditionally made at an advanced stage. More recently, predictive genetic BRCA testing is leading to the recognition in prophylactic oophorectomy specimens of clinically occult tubal carcinomas that are frequently in situ or small early-stage invasive carcinomas. These early lesions present a challenge in diagnosis and staging because the available criteria for the histopathologic diagnosis and staging of tubal carcinoma were derived from the clinicopathologic experience derived from the usual high-stage tubal carcinomas. The detection of early-stage tubal carcinomas requires that all tubal tissue be submitted for histologic examination. The diagnostic criteria for tubal in situ carcinoma have been defined, although the natural history of this lesion is unclear. Similarly defined criteria for a diagnosis of tubal dysplasia are lacking. Any early, invasive tubal carcinoma should be staged using a refined staging system suitable for early stage and fimbrial carcinomas. The adoption of these methods should increase our knowledge of early-stage tubal carcinoma and may add to our understanding of the development of ovarian-epithelial neoplasia.
Terence J Colgan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  22     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-21     Completed Date:  2003-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-20     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Carcinoma / genetics*,  pathology*
Fallopian Tube Neoplasms / genetics*,  pathology*
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Mass Screening
Neoplasm Staging
Ovarian Neoplasms / pathology
Comment In:
Int J Gynecol Pathol. 2003 Jul;22(3):315-6; author reply 315-6   [PMID:  12819403 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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