| Challenges in clinical design of immunotherapy trials for malignant glioma. | |
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MedLine Citation:
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PMID: 19944979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glioblastoma multiforme (GBM) is the most common and lethal primary malignant brain tumor. The traditional treatments for GBM, including surgery, radiation, and chemotherapy, only modestly improve patient survival. Therefore, immunotherapy has emerged as a novel therapeutic modality. Immunotherapeutic strategies exploit the immune system's ability to recognize and mount a specific response against tumor cells, but not normal cells. Current immunotherapeutic approaches for glioma can be divided into 3 categories: immune priming (active immunotherapy), immunomodulation (passive immunotherapy), and adoptive immunotherapy. Immune priming sensitizes the patient's immune cells to tumor antigens using various vaccination protocols. In the case of immunomodulation, strategies are aimed at reducing suppressive cytokines in the tumor microenvironment or using immune molecules to specifically target tumor cells. Adoptive immunotherapy involves harvesting the patient's immune cells, followed by ex vivo activation and expansion before reinfusion. This article provides an overview of the interactions between the central nervous system and the immune system, and discusses the challenges facing current immunotherapeutic strategies. |
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Authors:
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Cleo E Rolle; Sadhak Sengupta; Maciej S Lesniak |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurosurgery clinics of North America Volume: 21 ISSN: 1558-1349 ISO Abbreviation: Neurosurg. Clin. N. Am. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2009-12-24 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9008004 Medline TA: Neurosurg Clin N Am Country: United States |
Other Details:
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Languages: eng Pagination: 201-14 Citation Subset: IM |
Affiliation:
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The University of Chicago Brain Tumor Center, The University of Chicago, 5841 South Maryland Avenue, MC 3026, Chicago, IL 60637, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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therapy* Clinical Trials as Topic* Glioblastoma / therapy Glioma / therapy* Humans Immunization, Passive Immunotherapy* / methods Immunotherapy, Active Immunotherapy, Adoptive Research Design* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA138587-01A1/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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