| Challenges comparing functional limitations in rheumatoid arthritis and ankylosing spondylitis. | |
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MedLine Citation:
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PMID: 19822052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether physical functioning in patients with rheumatoid arthritis (RA) differs from that in patients with ankylosing spondylitis (AS) is presently uncertain. Such a comparison poses challenges, not only because the two diseases differ in the domains of functioning affected, but also because of the different instruments used to measure functional limitations. Limiting our analysis to studies using similar self-report questionnaires, we examined published observational studies of unselected cohorts of patients with RA and patients with AS to compare and contrast the severity of functional limitations. Available studies from a few direct comparisons, and mostly indirect comparisons, suggested that patients with RA are generally more severely limited in physical functioning throughout the disease course than patients with AS. Since most studies did not adjust adequately for potentially important confounders, such as age, gender, comorbidity, and disease duration, reported differences in functional disability between patients with RA and patients with AS must be interpreted cautiously. |
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Authors:
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G H Louie; J D Reveille; M M Ward |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 27 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-10-13 Completed Date: 2010-02-23 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: S83-91 Citation Subset: IM |
Affiliation:
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Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1468, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arthritis, Rheumatoid / physiopathology* Disability Evaluation* Female Health Status* Humans Male Middle Aged Severity of Illness Index* Spondylitis, Ankylosing / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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ZIA AR041153-05/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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