Document Detail

Challenges comparing functional limitations in rheumatoid arthritis and ankylosing spondylitis.
MedLine Citation:
PMID:  19822052     Owner:  NLM     Status:  MEDLINE    
Whether physical functioning in patients with rheumatoid arthritis (RA) differs from that in patients with ankylosing spondylitis (AS) is presently uncertain. Such a comparison poses challenges, not only because the two diseases differ in the domains of functioning affected, but also because of the different instruments used to measure functional limitations. Limiting our analysis to studies using similar self-report questionnaires, we examined published observational studies of unselected cohorts of patients with RA and patients with AS to compare and contrast the severity of functional limitations. Available studies from a few direct comparisons, and mostly indirect comparisons, suggested that patients with RA are generally more severely limited in physical functioning throughout the disease course than patients with AS. Since most studies did not adjust adequately for potentially important confounders, such as age, gender, comorbidity, and disease duration, reported differences in functional disability between patients with RA and patients with AS must be interpreted cautiously.
G H Louie; J D Reveille; M M Ward
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  27     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-10-13     Completed Date:  2010-02-23     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S83-91     Citation Subset:  IM    
Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1468, USA.
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MeSH Terms
Arthritis, Rheumatoid / physiopathology*
Disability Evaluation*
Health Status*
Middle Aged
Severity of Illness Index*
Spondylitis, Ankylosing / physiopathology*
Grant Support

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