| Challenges of antibacterial discovery. | |
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MedLine Citation:
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PMID: 21233508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of novel small-molecule antibacterial drugs has been stalled for many years. The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output of the effort. The major challenges fall into two areas: (i) proper target selection, particularly the necessity of pursuing molecular targets that are not prone to rapid resistance development, and (ii) improvement of chemical libraries to overcome limitations of diversity, especially that which is necessary to overcome barriers to bacterial entry and proclivity to be effluxed, especially in Gram-negative organisms. Failure to address these problems has led to a great deal of misdirected effort. |
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Authors:
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Lynn L Silver |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical microbiology reviews Volume: 24 ISSN: 1098-6618 ISO Abbreviation: Clin. Microbiol. Rev. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-14 Completed Date: 2011-04-14 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 8807282 Medline TA: Clin Microbiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 71-109 Citation Subset: IM |
Affiliation:
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LL Silver Consulting, LLC, 955 S. Springfield Ave., Unit C403, Springfield, NJ 07081, USA. silverly@comcast.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology*,
therapeutic use* Drug Discovery / methods*, trends* Drug Resistance, Bacterial Humans |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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