| Challenges and advances in the development of inhalable drug formulations for cystic fibrosis lung disease. | |
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MedLine Citation:
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PMID: 21375469 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Cystic fibrosis (CF) is a multisystem genetic disorder, which usually results in significant respiratory dysfunction. At present there is no cure for CF, but advances in pharmacotherapy have gradually increased the life expectancy of CF patients. As many drugs used in the therapy of CF are delivered by inhalation, the demand for effective and convenient inhalational CF drug formulations will grow as CF patients live longer. Knowledge of the current limitations in inhalational CF drug delivery is critical in identifying new opportunities and designing rational delivery strategies. Areas covered: This review discusses current and emerging therapeutic agents for CF therapy, selected physiological challenges to effective inhalational medication delivery, and various approaches to overcoming these challenges. The reader will find an integrated view of the known inhalational drug delivery challenges and the rationales for recent investigational inhalational drug formulations. Expert opinion: An ideal drug/gene delivery system to CF airways should overcome the tenacious sputum, which presents physical, chemical and biological barriers to effective transport of therapeutic agents to the targets and various cellular challenges. |
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Authors:
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Basma M Ibrahim; Michael D Tsifansky; Yan Yang; Yoon Yeo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-5 |
Journal Detail:
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Title: Expert opinion on drug delivery Volume: - ISSN: 1744-7593 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101228421 Medline TA: Expert Opin Drug Deliv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Purdue University, College of Pharmacy, Department of Industrial and Physical Pharmacy, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA +1 765 496 9608 ; +1 765 494 6545 ; yyeo@purdue.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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