Document Detail

Challenges of adherence management in human immunodeficiency virus pharmacotherapy.
MedLine Citation:
PMID:  14712324     Owner:  NLM     Status:  MEDLINE    
Medication adherence to highly active antiretroviral therapy (HAART) is currently a topic of major importance in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome care. HAART has dramatically reduced morbidity and mortality from HIV infection. Many people with HIV now live active and productive lives, with the disease itself having minimal impact on their lifespan. Unlike treatment for other chronic diseases, achieving the full benefit of HAART requires an extremely high level of adherence to potent antiretroviral combinations that is often difficult to achieve given the high pill burdens, drug interactions and adverse events associated with treatment. In this paper, the present knowledge regarding antiretroviral medication adherence is summarized with a focus on understanding the importance of adherence, the relationship between adherence and treatment response, the challenges and barriers facing patients trying to achieve optimal adherence, reasons for nonadherence, and the current directions and issues relevant to future adherence research.
Laura Y Park-Wyllie; Elizabeth J Phillips
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique     Volume:  10     ISSN:  1198-581X     ISO Abbreviation:  Can J Clin Pharmacol     Publication Date:  2003  
Date Detail:
Created Date:  2004-01-08     Completed Date:  2004-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9804162     Medline TA:  Can J Clin Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
Inner City Health Research Unit, St Michael's Hospital.
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MeSH Terms
Antiretroviral Therapy, Highly Active / adverse effects,  psychology,  utilization*
Drug Administration Schedule
Drug Resistance, Viral
HIV Infections / drug therapy*,  psychology
Patient Compliance*
Patient Education as Topic
Socioeconomic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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