Document Detail


Challenges associated with regeneration of orbital floor bone.
MedLine Citation:
PMID:  20645879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Orbital floor fractures are a serious consequence of craniofacial trauma and account for ∼60%-70% of all orbital fractures. Unfortunately, the body's natural response to orbital floor defects generally may not restore proper function and facial aesthetics, which is complicated by the thin bone and adjacent sinuses. Current clinical treatments include alloplastic implants and autologous grafts; however, each has associated disadvantages and sequelae. This review has outlined necessary components for a successful tissue-engineered construct for orbital floor repair. In addition, current successes and progress in the literature specific to orbital floors and craniofacial research have been reviewed. Finally, challenges and future directions have been described.
Authors:
Martha W Betz; John F Caccamese; Domenick P Coletti; John J Sauk; John P Fisher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Tissue engineering. Part B, Reviews     Volume:  16     ISSN:  1937-3376     ISO Abbreviation:  Tissue Eng Part B Rev     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466660     Medline TA:  Tissue Eng Part B Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-50     Citation Subset:  IM    
Affiliation:
Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials*
Bone Regeneration*
Humans
Orbital Fractures / surgery*
Prostheses and Implants
Tissue Engineering
Wound Healing*
Chemical
Reg. No./Substance:
0/Biocompatible Materials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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