| Chalcones derivatives acting as cell cycle blockers: potential anti cancer drugs? | |
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MedLine Citation:
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PMID: 19355861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chalcones (1,3-diphenylpropen-1-ones) are naturally occurring compounds belonging to the flavonoid family and are largely investigated in various therapeutic area and especially as antitumor drugs. In the latter field, the literature survey indicates that effect on the cell cycle is one of the most important targets domains of chalcones. In this review, we will shed light on: a) the structural criteria responsible for the cell cycle perturbations, b) the activity of chalcones on cell cycle molecular players or regulators c) the correlation between the chalcone-structure and proteins involved directly or not in cell cycle regulation and apoptosis by enhancement of proapoptotic molecules expression. We will discuss some perspectives related on how can we deal with chemical modification of chalcones to come up with more potent compounds to provide new ways for cancer treatment. |
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Authors:
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Ahcene Boumendjel; Xavier Ronot; Jean Boutonnat |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current drug targets Volume: 10 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-09 Completed Date: 2009-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 363-71 Citation Subset: IM |
Affiliation:
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Département de Pharmacochimie Moléculaire, UMR-CNRS, ICMG-FR- Université Joseph Fourier Grenoble I- France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemistry, pharmacology, therapeutic use* Cell Cycle / drug effects, physiology* Chalcones / chemistry, pharmacology, therapeutic use* Humans Neoplasms / drug therapy, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Chalcones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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