Document Detail

Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.
MedLine Citation:
PMID:  19616034     Owner:  NLM     Status:  MEDLINE    
The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.
Gerard Clarke; Siobhain M O'Mahony; Alan A Hennessy; Paul Ross; Catherine Stanton; John F Cryan; Timothy G Dinan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-16
Journal Detail:
Title:  Behavioural brain research     Volume:  205     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  319-21     Citation Subset:  IM    
Department of Psychiatry, University College Cork, Cork, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
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MeSH Terms
Arachidonic Acid / blood
Disease Models, Animal
Fatty Acids, Omega-3 / blood
Fatty Acids, Omega-6 / blood
Fatty Acids, Unsaturated / blood*
Maternal Deprivation*
Random Allocation
Rats, Sprague-Dawley
Stress, Psychological / blood*
Time Factors
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 506-32-1/Arachidonic Acid

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