Document Detail


Cetrorelix lowers premature luteinization rate in gonadotropin ovulation induction-intrauterine insemination cycles: a randomized-controlled clinical trial.
MedLine Citation:
PMID:  20810107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Attempting to compare the rates of premature luteinization (PL), clinical pregnancy, and cycle cancellation in ovulation induction-intrauterine insemination (OI-IUI) cycles with and without the GnRH antagonist, cetrorelix, a randomized-controlled trial was undertaken in which patients were randomized to one of two OI-IUI protocols. Those in the cetrorelix arm showed a significantly reduced rate of PL and no change in clinical pregnancy or cycle cancellation rate, leading to the conclusion that GnRH antagonists can decrease the rate of PL, but appear to have no effect on pregnancy or cycle cancellation in gonadotropin OI-IUI cycles.
Authors:
Ryan G Steward; Inderbir Gill; Dan B Williams; Craig A Witz; Jason Griffith; Ghassan F Haddad
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77225-0708, USA. Ryan.G.Steward@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Female
Gonadotropin-Releasing Hormone / administration & dosage,  analogs & derivatives*,  antagonists & inhibitors
Gonadotropins / therapeutic use
Hormone Antagonists / administration & dosage*
Humans
Infertility, Female / therapy*
Insemination, Artificial*
Luteinization / drug effects*
Ovulation Induction / methods*
Pregnancy
Pregnancy Outcome
Chemical
Reg. No./Substance:
0/Gonadotropins; 0/Hormone Antagonists; 33515-09-2/Gonadotropin-Releasing Hormone; OON1HFZ4BA/cetrorelix

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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