Document Detail


Cessation of reproduction-related spine elongation after multiple breeding cycles in female naked mole-rats.
MedLine Citation:
PMID:  18951517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The breeding female or "queen" naked mole-rat has a uniquely elongated body morphology attributed to the lengthening of the lumbar vertebral column that occurs during pregnancy. It is unknown whether this vertebral growth is a continuous process, or associated only with early reproductive experience. We compared pregnancy-related bone elongation in nascent primiparous queens and established queens to determine if this vertebral expansion was a lifelong process in these females. We also investigated the impact of lactation on vertebral elongation in these mole-rats because it is known to be a time of significant bone loss in other mammals. Our data show that after eight or more pregnancies, established queens no longer experienced a net gain in lumbar spine length over the reproductive cycle, whereas the nascent breeders demonstrated significant spine lengthening over this time. Despite the lack of net spine lengthening in established breeders, our results indicated that these queens still experienced some pregnancy-specific vertebral elongation. In naked mole-rats, pregnancy-induced bone elongation may serve the dual purposes of first lengthening the spine, and then once optimal spine size is achieved, serving as a homeostatic mechanism that prepares the spine for the mineral demands of lactation. Anat Rec, 2009. (c) 2008 Wiley-Liss, Inc.
Authors:
Christine M Dengler-Crish; Kenneth C Catania
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  292     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-11-09     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
Affiliation:
Neuroscience Program, Vanderbilt University, Nashville, Tennessee. christine.crish@vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Breeding*
Female
Male
Mole Rats
Pregnancy
Pregnancy, Animal / physiology*
Rats
Reproduction / physiology*
Spine / growth & development*
Grant Support
ID/Acronym/Agency:
DE 016061/DE/NIDCR NIH HHS; R01 DE016061-04/DE/NIDCR NIH HHS
Comments/Corrections

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