| Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. | |
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MedLine Citation:
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PMID: 2295405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cryptosporidium is a parasite of the human gastrointestinal tract that can cause life-threatening diarrhea in immunodeficient patients. Although more than 80 agents have been tried with occasional anecdotal success, treatment remains primarily limited to hydration. A 38-yr-old homosexual man with antibody to human immunodeficiency virus and Cryptosporidium-related diarrhea is described. The patient excreted 6-12 L of stool per day for at least 3 mo, 2 of them spent in the hospital. Trials with more than 6 antidiarrheal medications were ineffective. The patient received bovine colostrum hyperimmune to Cryptosporidium by direct duodenal infusion. During infusion, the patient's fecal output decreased to less than 2 L per day, and 48 h after treatment, stools were formed and oocysts to Cryptosporidium were absent. The patient remained asymptomatic for 3 mo. Hyperimmune bovine colostrum offers an exciting new therapy for cryptosporidiosis; controlled trials to establish efficacy should be undertaken and the active factor(s) characterized. |
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Authors:
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B L Ungar; D J Ward; R Fayer; C A Quinn |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 98 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-02-20 Completed Date: 1990-02-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 486-9 Citation Subset: AIM; IM; X |
Affiliation:
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Division of Tropical Public Health, Uniformed Services University of the Health Sciences, Bethesda, Maryland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Adult Animals Cattle Colostrum* Cryptosporidiosis / complications, therapy* Diarrhea / parasitology*, therapy Humans Immunotherapy / methods* Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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