Document Detail

Cesarean scar pregnancies successfully treated with methotrexate.
MedLine Citation:
PMID:  19330563     Owner:  NLM     Status:  MEDLINE    
Three cases of cesarean scar pregnancy successfully treated with methotrexate are described. The diagnosis was confirmed by transvaginal sonographic examinations showing a well-formed gestational sac in the myometrium of the lower uterine segment. Initial treatment with a systemic injection of 50 mg of methotrexate was not sufficient, and multiple doses were required to obtain a complete remission in two cases. In a case with a beta-hCG level of more than 20,000 mIU/mL with a viable embryo in a gestational sac, a combination of systemic and local treatment with methotrexate was required. It took 7-11 weeks for the beta-hCG level to become undetectable and 12-17 weeks for the cesarean scar pregnancy mass to disappear completely.
Miho Muraji; Seiji Mabuchi; Koji Hisamoto; Mariko Muranishi; Takeshi Kanagawa; Yukihiro Nishio; Tadashi Kimura
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  720-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / therapeutic use*
Abortion, Induced / methods
Cesarean Section / adverse effects*
Cicatrix / complications
Methotrexate / therapeutic use*
Pregnancy, Ectopic / drug therapy*,  ultrasonography
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

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