| Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children. | |
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MedLine Citation:
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PMID: 20478942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to analyze a possible association between cesarean delivery and enteric inflammatory diseases in children. METHODS: A retrospective, multicenter, case-control study that included 1950 children was performed in cooperation with 26 university and 16 nonacademic children's hospitals. Information on intestinal disease manifestation, together with mode of delivery and gestational age at birth, postnatal complications, and breastfeeding, was collected by the attending physician from children and their parents who were visiting a gastrointestinal outpatient clinic for Crohn disease (CD; 516 cases), ulcerative colitis (250 cases), celiac disease (157 cases), and other gastrointestinal diseases (165 cases) and control subjects who were visiting ophthalmologic, orthodontic, and dental outpatient clinics (862 cases). RESULTS: Whereas the rate of cesarean delivery of children with Crohn disease or ulcerative colitis was similar to that of control subjects, a significantly enhanced likelihood of being born by cesarean delivery was found in children with celiac disease compared with control subjects (odds ratio: 1.8 [95% confidence interval: 1.13-2.88]; P = .014). CONCLUSIONS: The mode of delivery and associated alterations in the development of the enteric homeostasis during the neonatal period might influence the incidence of celiac disease. |
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Authors:
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Evalotte Decker; Guido Engelmann; Annette Findeisen; Patrick Gerner; Martin Laass; Dietrich Ney; Carsten Posovszky; Ludwig Hoy; Mathias W Hornef |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-05-17 |
Journal Detail:
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Title: Pediatrics Volume: 125 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-07-27 Revised Date: 2010-08-13 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e1433-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Breast Feeding / statistics & numerical data Case-Control Studies Celiac Disease / epidemiology*, immunology Cesarean Section / adverse effects* Child Female Homeostasis Humans Inflammatory Bowel Diseases / epidemiology*, immunology Intestinal Mucosa / physiopathology Male Retrospective Studies |
| Comments/Corrections | |
Comment In:
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Nat Rev Gastroenterol Hepatol. 2010 Aug;7(8):418 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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