| Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition. | |
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MedLine Citation:
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PMID: 19019525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the changes of matrix metalloproteinase-9 (MMP-9) in cervicovaginal fluid during pregnancy and its association with parturition. STUDY DESIGN: A prospective study was conducted on nulliparous women between 16 and 42 weeks with normal singleton pregnancies in the following categories: (1) preterm control (n=39); (2) term labor induction without labor or rupture of membranes (n=68); (3) term spontaneous labor with intact membranes (n=42); (4) term premature rupture of membranes (n=24). The MMP-9 concentration in the cervicovaginal fluid was measured by immunoassay. RESULTS: (1) Cervicovaginal MMP-9 did not change significantly with advancing gestation until 37 weeks, and significantly increased after 37 weeks. (2) Cervicovaginal MMP-9 levels were similar in women with no labor, spontaneous labor, and premature rupture of membranes at term. (3) For the induced labor group, a high Bishop score (>or=4) was significantly correlated with cervicovaginal MMP-9. However, an elevated cervicovaginal MMP-9 did not predict achieving active phase of labor or vaginal delivery after labor induction. CONCLUSION: Cervicovaginal MMP-9 correlated with cervical ripening before labor at term. However, cervicovaginal MMP-9 did not change with spontaneous labor or rupture of membranes at term and did not predict success of labor induction. |
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Authors:
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Suk-Joo Choi; Kyung-Lan Jung; Soo-young Oh; Jong-Hwa Kim; Cheong-Rae Roh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-18 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 142 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 43-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Fluids / enzymology Cervical Ripening / physiology* Cervix Uteri / enzymology Female Fetal Membranes, Premature Rupture / enzymology Gestational Age Humans Matrix Metalloproteinase 9 / metabolism* Parturition / physiology* Pregnancy Vagina / enzymology |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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