Document Detail

Cervicovaginal involvement in pemphigus vulgaris: a clinical study of 77 cases.
MedLine Citation:
PMID:  18070212     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pemphigus vulgaris (PV) is an autoimmune blistering disease which is known to involve the female genital tract, but the frequency at which this occurs is unknown. There are few reports in the literature of the cytological appearance of PV on cervicovaginal smears. OBJECTIVES: To evaluate involvement of the female genital tract and the appearance of cervicovaginal Papanicolaou (Pap) smears in PV. METHODS: The study included 77 patients with PV who attended between April 2005 and February 2007. Each patient was subjected to gynaecological examination and cervicovaginal Pap smear. RESULTS: Genital lesions were observed in 39 patients (51%). Of these, the labia minora were involved in 36 patients (92%), the labia majora in 11 (28%), the vagina in 14 (36%) and the cervix in six (15%). Cervicovaginal Pap smears of 20 of 77 patients (26%) showed PV. Of 72 satisfactory Pap smears, the cervical Pap smear was normal in 25 patients (35%), inflammatory in 43 patients (60%), and dysplastic (low-grade squamous intraepithelial neoplasia) in four patients (6%). CONCLUSIONS: Involvement of the female genital tract with PV might not be as infrequent as was previously thought; it is probably the second most common mucosal site of PV after the oral mucosa. Genital lesions may be missed and the need for thorough pelvic examination should not be overlooked.
M Akhyani; C Chams-Davatchi; Z Naraghi; M Daneshpazhooh; S Toosi; M Asgari; F Malekhami
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-12-06
Journal Detail:
Title:  The British journal of dermatology     Volume:  158     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  478-82     Citation Subset:  IM    
Department of Dermatology, Tehran University of Medical Sciences, Razi Hospital, Tehran 1199663911, Iran.
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MeSH Terms
Aged, 80 and over
Cervix Uteri / pathology*
Middle Aged
Pemphigus / pathology*
Precancerous Conditions / pathology
Treatment Outcome
Vaginal Smears / methods

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