Document Detail


Cervical-vaginal and intraanal human papillomavirus infection of young girls with external genital warts.
MedLine Citation:
PMID:  8035020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To expand information regarding the epidemiology of genital human papillomavirus (HPV) infection in young girls, girls with external genital warts were examined for the prevalence of cervical-vaginal or intraanal HPV infection. Cervical-vaginal wash specimens and biopsies of external lesions were examined for HPV genotypes 1, 2, 4, 6, 11, and 16 using Southern transfer hybridization with restriction endonuclease fragment length analysis. Exfoliated cells from cervical-vaginal and intraanal canals were processed for cytologic study. Of 18 girls, 8 (44%) had cytologic or genomic evidence (or both) of cervical-vaginal or intraanal HPV infection. Five had cervical-vaginal wash specimens that were positive for HPV genome and showed mild dysplasia. As is true for adults, young girls with external anal-genital warts are also frequently infected with HPV at internal mucosal sites. Determining the immediate and long-term prognosis of infected children and those with intraepithelial neoplasia will require appropriate prospective studies.
Authors:
L T Gutman; K K St Claire; V D Everett; D L Ingram; J Soper; W W Johnston; G G Mulvaney; W C Phelps
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  170     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-08-18     Completed Date:  1994-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Descriptor/Qualifier:
Anus Diseases / complications,  epidemiology
Blotting, Southern
Cervix Uteri / pathology,  virology
Child
Child Abuse, Sexual
Child, Preschool
Condylomata Acuminata / complications*
DNA, Viral / analysis
Female
Genital Diseases, Female / complications*
Genome, Viral
Humans
Infant
Papillomaviridae / classification,  genetics,  isolation & purification*
Papillomavirus Infections / complications,  epidemiology*
Prevalence
Tumor Virus Infections / complications,  epidemiology*
Uterine Cervical Diseases / complications,  epidemiology
Uterine Cervical Dysplasia / complications,  epidemiology
Vagina / pathology,  virology
Vaginal Diseases / complications,  epidemiology
Vaginal Smears
Chemical
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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