Document Detail

Cervical softening occurs early in pregnancy: characterization of cervical stiffness in 100 healthy women using the aspiration technique.
MedLine Citation:
PMID:  23553612     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To quantitatively describe the evolution of ecto-cervical stiffness in normal pregnancy. METHODS: The stiffness of ecto-cervical tissue was measured using the aspiration method. This non-invasive technique allows to safely and objectively determining the pressure required to displace cervical tissue to a predefined deformation level (pcl ). In this prospective study, 448 aspiration measurements were carried out on pregnant women (n = 50) at each of the eight routine pregnancy consultations and on non-pregnant subjects (reference, n = 50). pcl values were grouped as non-pregnant, first, second, third trimester, and post-partum. RESULTS: Stiffness in early pregnancy (first trimester) is significantly lower, by a factor > 2 for the mean value, than for the non-pregnant group. pcl continuously decreases during gestation, with significant differences between first and second trimester , but not between second and third trimester. After delivery consistency is recovered to the level of early pregnancy. CONCLUSIONS: The aspiration method allows an objective description of the consistency of the ecto-cervix during pregnancy, indicating that the tissue softens already at the beginning of gestation, transforms continuously to lower consistency in the first two trimesters, stabilizes at a low level in the third trimester, and recovers its stiffness after delivery. © 2013 John Wiley & Sons, Ltd.
Sabrina Badir; Edoardo Mazza; Roland Zimmermann; Michael Bajka
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-3
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons, Ltd.
Center of Mechanics, Swiss Federal Institute of Technology Zurich, Tannenstrasse 3, 8092, Zurich, Switzerland.
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