| Cervical pregnancy treated with transvaginal ultrasound-guided intra-amniotic instillation of methotrexate. | |
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MedLine Citation:
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PMID: 15655698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Aim of the study was to investigate the efficacy of single transvaginal ultrasound-guided intraamniotic installation of methotrexate in the management of cervical pregnancy with concurrent review of the literature. MATERIALS AND METHODS: Six patients with cervical pregnancy are included in the study. All patients were treated with single transvaginal ultrasound-guided intraamniotic installation of 70 mg of methotrexate plus folic acid p.o. The main presenting symptoms were mild to moderate vaginal bleeding and lower abdominal cramp-like pain, resembling the clinical presentation of a threatened abortion. The typical ultrasound findings were the absence of intrauterine gestational sac and the detection of a gestational sac within the cervical canal, invading the anterior or the posterior wall of the cervix and normal appearance of the adnexa, bilaterally. The hourglass-shaped cervix was not characteristic at 5 weeks of gestation but it was at 8 weeks of gestation. DISCUSSION: Ultrasound-guided intraamniotic installation of methotrexate in the management of cervical pregnancy appears to be an effective and safe method but the choice of the method should be depended on the gestational age of cervical pregnancy, the presence of active bleeding or not and its severity, the desire for preservation of future fertility, the presence of coexisting valuable intrauterine pregnancy and the experience of the physician in charge. |
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Authors:
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D Hassiakos; P Bakas; G Creatsas |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2004-01-14 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 271 ISSN: 0932-0067 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-18 Completed Date: 2006-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 69-72 Citation Subset: IM |
Affiliation:
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2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens, Alexandras Avenue 108, 11522 Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage*,
therapeutic use Amnion Cervix Uteri Female Gestational Age Humans Instillation, Drug Methotrexate / administration & dosage*, therapeutic use Pregnancy Pregnancy Outcome Pregnancy, Ectopic / drug therapy*, ultrasonography Ultrasonography, Doppler, Color Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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