Document Detail


Cervical light-induced fluorescence in humans decreases throughout gestation and before delivery: Preliminary observations.
MedLine Citation:
PMID:  12592268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to investigate gestational changes of cervical light-induced fluorescence, an index of cross-linked collagen, and the relationship between light-induced fluorescence and the time-to-delivery interval. STUDY DESIGN: Fifty patients were included in one of two groups. (1) Twenty-one healthy pregnant women without signs of labor underwent repeated cervical light-induced fluorescence measurement during the last trimester. (2) Light-induced fluorescence was measured in 29 patients with signs of labor, and the time from measurement to delivery was noted. Cervical light-induced fluorescence was obtained noninvasively with a prototype instrument that was designed specifically for this purpose. Spearman correlation and the Student t test and receiver-operator characteristics analysis were performed (P <.05). RESULTS: Light-induced fluorescence correlated negatively with gestational age and positively with time-to-delivery interval, was significantly lower in patients who were delivered <24 hours compared with those patients who were delivered >24 hours later, and was predictive of delivery within 24 hours. CONCLUSION: Cervical light-induced fluorescence decreases significantly as gestational age increases. Light-induced fluorescence may be a useful tool to identify patients in whom delivery is imminent.
Authors:
Holger Maul; Gayle Olson; Cordula T Fittkow; George R Saade; Robert E Garfield
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  188     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-19     Completed Date:  2003-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  537-41     Citation Subset:  AIM; IM    
Affiliation:
Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, 77555, USA.
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MeSH Terms
Descriptor/Qualifier:
Cervix Uteri / physiology*,  radiation effects*
Delivery, Obstetric*
Female
Fluorescence*
Forecasting
Gestational Age
Humans
Light*
Pregnancy
Sensitivity and Specificity
Time Factors
Grant Support
ID/Acronym/Agency:
M01 RR00073/RR/NCRR NIH HHS; R01-37480//PHS HHS

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