| Cervical leukocyte sub-populations in idiopathic preterm labour. | |
| | |
MedLine Citation:
|
PMID: 17275097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate cervical epithelial leukocyte sub-populations in pregnant women with a history of idiopathic preterm labour. METHODS: A prospective observational study was undertaken of 106 women with a past history of idiopathic preterm delivery following spontaneous labour. A cytobrush was used to sample the epithelium of the cervix at 12-16 weeks of gestation and again 8 weeks later. All women had investigations for cervical and vaginal infection as well as serial transvaginal ultrasonography of their cervix; the mode and gestation at delivery were recorded. Leukocyte sub-populations were examined using immunocytochemistry, and the number of leukocytes per total cell count was calculated. MAIN OUTCOME MEASURES: Cervical epithelial leukocytes populations were (1) described in pregnancy, (2) observed over increasing gestation, (3) analysed in women who developed marked cervical shortening and (4) in those whose preterm labour recurred. RESULTS: There was no significant change in cervical epithelial leukocyte populations during the second trimester of pregnancy. There was no association between cervical leukocytes and cervical shortening. Women with idiopathic preterm labour that recurred had fewer cervical macrophages at the beginning of the second trimester of pregnancy than those whose subsequent pregnancy progressed beyond 35 weeks of gestation. CONCLUSIONS: Cervical epithelial macrophages may serve to prevent recurrent preterm labour, possibly by preventing ascending infection. |
| | |
Authors:
|
M K Whitworth; I Pafilis; G Vince; S Quenby |
Related Documents
:
|
10227677 - Morphology of the cervical vertebrae in the fetal-neonatal human skeleton. 19039797 - Emergency cerclage in cases of twin-to-twin transfusion syndrome with a short cervix at... 20840527 - Proportion of excision and cervical healing after large loop excision of the transforma... 7970477 - Cervical changes throughout pregnancy as assessed by transvaginal sonography. 51697 - Fetal hypothyroidism complicating medical treatment of thyrotoxicosis in pregnancy. 11013697 - Multiple cerebellar haemangioblastomas symptomatic during pregnancy. |
Publication Detail:
|
Type: Journal Article Date: 2007-02-01 |
Journal Detail:
|
Title: Journal of reproductive immunology Volume: 75 ISSN: 0165-0378 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-27 Completed Date: 2007-11-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 48-55 Citation Subset: IM |
Affiliation:
|
University of Liverpool, Department of Reproductive and Developmental Medicine, Liverpool Women's NHS Foundation Trust, Liverpool L8 7SS, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antigens, CD / analysis Cervix Uteri / immunology* Female Humans Leukocytes / cytology* Lymphocyte Subsets / immunology Macrophages Obstetric Labor, Premature / immunology*, physiopathology Pregnancy Pregnancy Trimester, Second Prospective Studies Vaginal Smears |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Psychopathology in children of bipolar parents.
Next Document: Failure of antigen-stimulated gammadelta T cells and CD4+ T cells from sensitized cattle to upregula...