| Cervical length changes during preterm cervical ripening: effects of 17-alpha-hydroxyprogesterone caproate. | |
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MedLine Citation:
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PMID: 17466698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate whether 17-alpha-hydroxyprogesterone caproate (17P) treatment affect changes in cervical length. STUDY DESIGN: Women with singleton pregnancy, between 25 and 33 + 6 weeks of gestation, who were hospitalized for preterm labor were included. Patients with rupture of membranes and/or signs of chorioamnionitis were excluded. Sixty undelivered patients were allocated randomly to either observation or to receive 341 mg of 17P intramuscularly, twice each week until gestational week 36. Cervical length was measured by transvaginal ultrasound scanning at discharge and at day 7 and 21 after discharge. Statistical comparisons were done with analysis of variance and chi-square test. RESULTS: Shortening of the cervix in the observation group (30 cases) was higher than in the 17P group (30 cases) both at day 7 (2.37 +/- 2.0 mm vs 0.83 +/- 1.74 mm; P = .002) and day 21 (4.60 +/- 2.73 mm vs 2.40 +/- 2.46 mm; P = .002). Treatment with 17P was associated with both a reduction in the risk of cervical shortening of > or = 4 mm (odds ratio, 0.18; 95% CI, 0.04-0.66) and in the risk of preterm delivery (odds ratio, 0.15; 95% CI, 0.04-0.58). CONCLUSION: Undelivered patients after preterm labor undergo progressive shortening of the cervix, which is attenuated by 17P treatment. |
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Authors:
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Fabio Facchinetti; Simone Paganelli; Giuseppina Comitini; Giulia Dante; Annibale Volpe |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 196 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-30 Completed Date: 2007-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 453.e1-4; discussion 421 Citation Subset: AIM; IM |
Affiliation:
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Unit of Obstetrics, Mother-Infant Department, University of Modena and Reggio Emilia, Reggio Emilia, Italy. Facchi@unimore.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxyprogesterone
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pharmacology*,
therapeutic use Caproates / pharmacology* Cervical Ripening / drug effects* Cervix Uteri / drug effects*, ultrasonography Female Gonadal Steroid Hormones / pharmacology*, therapeutic use Humans Obstetric Labor, Premature / prevention & control Pregnancy Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Caproates; 0/Gonadal Steroid Hormones; 68-96-2/17-alpha-Hydroxyprogesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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