| Cervical length and cervicovaginal HCG for prediction of pre-term birth in women with signs and symptoms of pre-term labour. | |
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MedLine Citation:
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PMID: 20604645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study group consisted of 100 women with a singleton pregnancy with pre-term labour between 26-36 weeks' gestation. Cervicovaginal secretions were collected for HCG assay and cervical length was measured by transvaginal sonography (TVS). These parameters were analysed to predict pre-term birth. The pre-term delivery rate was 55%; 24% delivered within 48 h and 11% within 7 days of admission. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of cervical length <or=2.5 cm to predict delivery within 48 h and 7 days of admission were 62.5%, 89.5%, 65.2%, 88.3% and 60.0%, 96.9%, 91.3%, 81.8% respectively; and those of qualitative HCG were 87.5%, 80.3%, 58.3%, 95.3% and 77.1%, 86.2%, 75%, 87.5% respectively. HCG value of >or=45 mIU/ml was the optimal cut-off, with a sensitivity, specificity, PPV and NPV for predicting delivery within 48 h and 7 days to be 95.8%, 73.7%, 53.5% and 98.2% and 85.7%, 80%, 69.8% and 91.2%, respectively. Combining either qualitative or quantitative HCG assay with cervical length significantly increased the sensitivity and NPV of cervical length alone for prediction of pre-term delivery both within 48 h and 7 days. It was concluded that increased cervicovaginal HCG and reduced cervical length predicted an increased risk of pre-term delivery in women with pre-term labour. Qualitative cervicovaginal HCG assay may be used as a bedside test to predict pre-term delivery within 48 h or within 7 days. |
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Authors:
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R Bagga; M Takhtani; V Suri; K Adhikari; S Arora; S Bhardwaj |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Volume: 30 ISSN: 1364-6893 ISO Abbreviation: J Obstet Gynaecol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-07 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309140 Medline TA: J Obstet Gynaecol Country: England |
Other Details:
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Languages: eng Pagination: 451-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervical Length Measurement* Cervix Uteri / ultrasonography* Chorionic Gonadotropin / metabolism Female Humans Obstetric Labor, Premature / epidemiology, metabolism, ultrasonography* Predictive Value of Tests Pregnancy Pregnancy Outcome Risk Factors Sensitivity and Specificity Vagina / metabolism, secretion Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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