Document Detail

Cervical insulin-like growth factor binding protein-1 (IGFBP-1) to predict spontaneous onset of labor and induction to delivery interval in post-term pregnancy.
MedLine Citation:
PMID:  21275916     Owner:  NLM     Status:  In-Data-Review    
Objective. To evaluate whether insulin-like growth factor binding protein-1 (IGFBP-1) assessed in cervical secretion can predict successful induction and spontaneous onset of labor in post-term pregnancy, compared to ultrasound measurement of cervical length and Bishop score. Design. Cohort study, originating from a randomized controlled trial. Setting. Obstetric department of a university and tertiary referral hospital, Norway. Population. Five hundred and eight post-term women who had been randomized to induction of labor or expectant management 1 week beyond estimated day of delivery (289 [±2] days of gestation). Methods. Time to delivery was related to presence of IGFBP-1 in cervical secretion, Bishop score and ultrasound measurement of cervical length recorded at inclusion. Main outcome measures. Spontaneous onset of labor and delivery within 3 days in the expectant management, and delivery within 24 hours of induction in the induction group. Test characteristics (sensitivity, specificity and negative and positive values and likelihood ratios) for IGFBP-1, Bishop score and cervical length were calculated. Logistic regression and Cox regression were used to account for parity and body mass index. Results. With expectant management, IGFBP-1 predicted spontaneous labor onset and delivery within 72 hours with low sensitivity and high specificity (0.45 and 0.80, respectively), as did Bishop score (0.24, 0.92). Cervical length was more sensitive (0.67, 0.58). IGFBP-1 predicted successful induction within 24 hours with low sensitivity and high specificity (0.30, 0.85), such as Bishop score (0.06, 1.00) and cervical length (0.45, 0.76). Parity enhanced successful induction. Conclusion. IGFBP-1 predicts both spontaneous labor onset and successful induction in post-term pregnancy. Bishop score and cervical length performed equally well.
Malin Dögl; Eirik Skogvoll; Runa Heimstad
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Publication Detail:
Type:  Journal Article     Date:  2010-11-26
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  90     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2010 Nordic Federation of Societies of Obstetrics and Gynecology.
Department of Gynecology and Obstetrics, Levanger Hospital, Health Trust Nord-Trøndelag Department of Obstetrics Anaesthesiology and Emergency Medicine, St. Olav University Hospital Trondheim Institute of Cancer research and Molecular Medicine, Faculty of Medicine Institute of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
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