Document Detail

Cervical fluid cytokines in pregnant women: Relation to vaginal wet mount findings and polymorphonuclear leukocyte counts.
MedLine Citation:
PMID:  18406509     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of the study was to measure and compare concentrations of IFN-gamma, IL-8, IL-10 and IL-12 in cervical fluids of pregnant women with normal and pathologic microscopic findings of vaginal wet mount. STUDY DESIGN: Vaginal samples were obtained from 100 pregnant women (22-32 weeks of gestation) without signs and symptoms of preterm labour (PTL), selected on the basis of the microscopic examination of vaginal wet mounts. Cytokine (IFN-gamma, IL-8, IL-10 and IL-12) concentrations were measured in cervical fluids by an enzyme-linked immunosorbent assay. RESULTS: The cytokines were found in cervical fluids of the majority of pregnant women, with IFN-gamma and IL-8 detected in all samples. Concentrations of IL-8 were significantly higher in pregnant women with pathologic findings on vaginal wet mount, including elevated polymorphonuclear (PMN) cell counts. CONCLUSION: A significant correlation between microscopic findings and cervical fluid IL-8 concentrations may make vaginal wet mount microscopy a useful tool for identification of patients with cervicovaginal inflammation, which is considered a risk factor for spontaneous preterm delivery.
Dane B Nenadić; Milos D Pavlović
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-04-11
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  140     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2008-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Departments of Gynecology, Military Medical Academy, Belgrade, Serbia.
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MeSH Terms
Bodily Secretions / metabolism*,  microbiology
Candidiasis, Vulvovaginal / immunology,  metabolism,  microbiology
Cervix Uteri / microbiology,  secretion*
Interferon-gamma / metabolism
Interleukin-8 / metabolism*
Leukocyte Count
Neutrophils / immunology
Pregnancy / immunology,  metabolism*
Vagina / immunology*,  microbiology
Vaginosis, Bacterial / immunology,  metabolism,  microbiology
Reg. No./Substance:
0/Interleukin-8; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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