| Cervical fetal fibronectin as a predictor of first trimester pregnancy outcome in unexplained recurrent miscarriage. | |
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MedLine Citation:
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PMID: 16256259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether cervical fetal fibronectin is a reliable predictor of first trimester pregnancy outcome in patients with unexplained recurrent miscarriage. STUDY DESIGN: A prospective observational study was carried out on 49 pregnant women with a history of unexplained recurrent miscarriage. In all participants the presence of fetal fibronectin in the cervical secretion was determined with a qualitative rapid immunoassay. The outcome of the first trimester pregnancy was recorded a successful outcome was a pregnancy that progressed beyond 12 weeks of gestation; a miscarriage referred to a pregnancy loss in the first 12 weeks. RESULTS: Of the 49 subjects screened, fetal fibronectin was positive in 17 and negative in 32. Overall, 14 pregnancies resulted in fetal loss before the 12th week of gestation. Fetal cervical fibronectin was positive in 6 of the 14 patients who miscarried and in 11 of the 35 in whom outcome was successful. As predictor of first trimester pregnancy outcome the test had a sensitivity and a specificity of 43% and 69% and positive and negative predictive values of 35%, and 75%, respectively. Subgroup analysis by number of previous miscarriages and maternal age gave similar values. CONCLUSION: This study examines the possible value of cervical fetal fibronectin in predicting first trimester pregnancy outcome. We conclude that the occurrence of positive or negative fetal cervical fibronectin test has only limited predictive value and therefore its use cannot be considered for clinical application. |
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Authors:
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Francesco Mercorio; Antonio Mercorio; Attilio Di Spiezio Sardo; Carmela Votino; Gian Vincenzo Barba; Carmine Nappi |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2005-10-26 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 126 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-29 Completed Date: 2006-08-08 Revised Date: 2006-08-09 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 165-9 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obsterics, and Pathophysiology of Human Reproduction, University of Naples Federico II, Via L. Caldieri 140, 80128 Naples, Italy. fmercorio@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual* Adult Cervix Uteri / secretion* Female Fetal Proteins / secretion* Fibronectins / secretion* Humans Predictive Value of Tests Pregnancy Pregnancy Outcome Pregnancy Trimester, First Prospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Fetal Proteins; 0/Fibronectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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