Document Detail


Cervical dysplasia in pregnancy: a multi-institutional evaluation.
MedLine Citation:
PMID:  20522409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was undertaken to identify the prognostic indicators associated with postpartum regression of cervical dysplasia diagnosed in pregnancy. STUDY DESIGN: A retrospective cohort study of pregnant women referred for colposcopy from 2004-2007 at four academic centers. RESULTS: One thousand seventy-nine patients were identified. Colposcopic impression by cervical cytology is detailed later in the text. Of patients who underwent biopsy, results correlated with or were less severe than colposcopic impression in 83% with CIN 1 and 56% with CIN 2/3. Fifty-seven percent had follow-up postpartum, with 61% reverting to normal. Resolution of cervical dysplasia was inversely associated with smoking (P = .002). No progression to cancer occurred during pregnancy. CONCLUSION: Colposcopic impression in pregnancy correlated with cervical biopsy results and postpartum colposcopic findings when performed by expert colposcopists. A high proportion of cervical dysplasia regressed postpartum. Cervical biopsies in pregnancy may not be necessary unless invasive cancer is suspected.
Authors:
Amanda N Fader; Erin K Alward; Amy Niederhauser; Christina Chirico; Jamie L Lesnock; Daniel J Zwiesler; Richard S Guido; Darla J Lofgren; Michael A Gold; Kathleen N Moore
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2010-06-03
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Greater Baltimore Medical Center/Johns Hopkins Medical Institutions, Baltimore, MD 21204, USA. amandanfader@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Academic Medical Centers
Adult
Age Distribution
Biopsy, Needle
Cervical Intraepithelial Neoplasia / diagnosis,  epidemiology,  pathology*
Cohort Studies
Colposcopy / methods
Female
Follow-Up Studies
Gestational Age
Humans
Immunohistochemistry
Incidence
Multivariate Analysis
Precancerous Conditions / epidemiology,  pathology
Pregnancy
Pregnancy Complications, Neoplastic / epidemiology*,  pathology
Pregnancy Outcome*
Prenatal Care
Probability
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Uterine Cervical Dysplasia / diagnosis,  epidemiology*,  pathology*
Uterine Neoplasms / diagnosis,  epidemiology,  pathology*
Vaginal Smears
Young Adult
Grant Support
ID/Acronym/Agency:
M01 RR-14467/RR/NCRR NIH HHS; N02-CP-31102/CP/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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