| Cervical carcinoma and reproductive factors: collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies. | |
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MedLine Citation:
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PMID: 16570271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The International Collaboration of Epidemiological Studies of Cervical Cancer has combined individual data on 11,161 women with invasive carcinoma, 5,402 women with cervical intraepithelial neoplasia (CIN)3/carcinoma in situ and 33,542 women without cervical carcinoma from 25 epidemiological studies. Relative risks (RRs) and 95% confidence intervals (CIs) of cervical carcinoma in relation to number of full-term pregnancies, and age at first full-term pregnancy, were calculated conditioning by study, age, lifetime number of sexual partners and age at first sexual intercourse. Number of full-term pregnancies was associated with a risk of invasive cervical carcinoma. After controlling for age at first full-term pregnancy, the RR for invasive cervical carcinoma among parous women was 1.76 (95% CI: 1.53-2.02) for > or => or =7 full-term pregnancies compared with 1-2. For CIN3/carcinoma in situ, no significant trend was found with increasing number of births after controlling for age at first full-term pregnancy among parous women. Early age at first full-term pregnancy was also associated with risk of both invasive cervical carcinoma and CIN3/carcinoma in situ. After controlling for number of full-term pregnancies, the RR for first full-term pregnancy at age <17 years compared with > or => or =25 years was 1.77 (95% CI: 1.42-2.23) for invasive cervical carcinoma, and 1.78 (95% CI: 1.26-2.51) for CIN3/carcinoma in situ. Results were similar in analyses restricted to high-risk human papilloma virus (HPV)-positive cases and controls. No relationship was found between cervical HPV positivity and number of full-term pregnancies, or age at first full-term pregnancy among controls. Differences in reproductive habits may have contributed to differences in cervical cancer incidence between developed and developing countries. |
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Authors:
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Publication Detail:
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Type: Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 119 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-06-12 Completed Date: 2006-08-22 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1108-24 Citation Subset: IM |
Copyright Information:
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Copyright 2006 Wiley-Liss, Inc. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Carcinoma / epidemiology*, physiopathology Case-Control Studies Cervical Intraepithelial Neoplasia / epidemiology Cohort Studies Female Humans International Cooperation Parity Pregnancy Reproduction* Risk Assessment Risk Factors Uterine Cervical Neoplasms / epidemiology*, physiopathology World Health Organization |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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