Document Detail


Cervical adenocarcinoma in situ: the predictive value of conization margin status.
MedLine Citation:
PMID:  17689647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma in situ. STUDY DESIGN: A retrospective chart review identified patients at a University hospital from 1988-2006 with adenocarcinoma in situ (AIS) on conization. RESULTS: Seventy-four patients were included. Median follow-up was 26 months. Twenty-two of 74 patients (30%) had positive margins, 46 patients (62%) had negative margins, and 6 patients had indeterminate margins. Of patients with positive margins, 55% (12/22) were diagnosed with residual or recurrent disease, including 3 patients diagnosed with adenocarcinoma on hysterectomy. Thirteen percent of patients with negative conization margins (6/46) were diagnosed with residual or recurrent disease, including 2 patients diagnosed with adenocarcinoma during follow-up. Cold knife conization resulted in a significantly higher number of negative margins compared to other conization procedures (P = .013). CONCLUSIONS: Even with negative conization margins, women still face a risk of residual, recurrent, or invasive disease.
Authors:
Jennifer L Young; Amir A Jazaeri; Jason A Lachance; Mark H Stoler; William P Irvin; Laurel W Rice; Willie A Andersen; Susan C Modesitt
Related Documents :
21689327 - Accuracy of measurement of puborectal contraction by perineal ultrasound in patients wi...
646487 - Staging laparotomy in hodgkin's disease.
16077337 - Protective pneumothorax for needle biopsy of mediastinum and pulmonary hilum.
21274877 - Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
20015127 - Local activation time derived from stored egm is associated with failure of antitachyca...
17639097 - Ischaemic symptoms, quality of care and mortality during myocardial infarction.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195.e1-7; discussion 195.e7-8     Citation Subset:  AIM; IM    
Affiliation:
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville 22908-0712, USA. jly2y@virginia.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology*
Adolescent
Adult
Aged
Carcinoma in Situ / pathology*
Cervix Uteri / pathology*
Conization*
Female
Humans
Middle Aged
Neoplasm, Residual
Predictive Value of Tests
Retrospective Studies
Uterine Cervical Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intrauterine device use in a high-risk population: experience from an urban university clinic.
Next Document:  The "Hispanic paradox": an investigation of racial disparity in pregnancy outcomes at a te...