Document Detail

Cervical adenocarcinoma in situ: the predictive value of conization margin status.
MedLine Citation:
PMID:  17689647     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma in situ. STUDY DESIGN: A retrospective chart review identified patients at a University hospital from 1988-2006 with adenocarcinoma in situ (AIS) on conization. RESULTS: Seventy-four patients were included. Median follow-up was 26 months. Twenty-two of 74 patients (30%) had positive margins, 46 patients (62%) had negative margins, and 6 patients had indeterminate margins. Of patients with positive margins, 55% (12/22) were diagnosed with residual or recurrent disease, including 3 patients diagnosed with adenocarcinoma on hysterectomy. Thirteen percent of patients with negative conization margins (6/46) were diagnosed with residual or recurrent disease, including 2 patients diagnosed with adenocarcinoma during follow-up. Cold knife conization resulted in a significantly higher number of negative margins compared to other conization procedures (P = .013). CONCLUSIONS: Even with negative conization margins, women still face a risk of residual, recurrent, or invasive disease.
Jennifer L Young; Amir A Jazaeri; Jason A Lachance; Mark H Stoler; William P Irvin; Laurel W Rice; Willie A Andersen; Susan C Modesitt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195.e1-7; discussion 195.e7-8     Citation Subset:  AIM; IM    
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville 22908-0712, USA.
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MeSH Terms
Adenocarcinoma / pathology*
Carcinoma in Situ / pathology*
Cervix Uteri / pathology*
Middle Aged
Neoplasm, Residual
Predictive Value of Tests
Retrospective Studies
Uterine Cervical Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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