Document Detail


Cervical Ribs are More Prevalent in Stillborn Fetuses than in Liveborn Infants and are Strongly Associated with Fetal Aneuploidy.
MedLine Citation:
PMID:  21711209     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract This study was undertaken to determine the prevalence of cervical ribs in stillborn fetuses undergoing autopsy at our institution and to search for significant associations with cervical ribs. European studies have reported an increased prevalence of cervical ribs in patients with childhood cancer, and in stillborn fetuses. We reviewed data from autopsies performed at Primary Children's Medical Center, Utah between 2006 and 2009 on 225 stillborns (≥ 20 weeks) and 93 liveborn infants (< 1 year). Digital fetal radiographs in anterior-posterior and lateral views were taken on each of these autopsies. Chi-square analysis and general linear models were used for statistical analysis of the data. The overall prevalence of cervical ribs was higher in stillborns than in liveborn controls (43.1% vs 11.8%). Karyotypes were available on 93 (41.3%) of the stillborns. Of those, cervical ribs were present in 33 of 76 (43.4%) stillborns with normal karyotype, and in 13 of 17 (76.4%) stillborns with aneuploidy. Females with unavailable karyotypes were more likely to have cervical ribs than those with normal karyotypes (p = 0.0002). This greater likelihood was not observed in males. Among the stillborns with normal karyotypes, we found no statistically significant association with gender or gestational age at fetal death. There was also no statistically significant association between congenital anomalies and the presence of cervical ribs. Our findings support the hypothesis that cervical ribs are markers for disadvantageous developmental events occurring during blastogenesis, and have been subject to strong negative selection during evolution.
Authors:
Larissa V Furtado; Harshwardhan M Thaker; Lance K Erickson; Brian H Shirts; John Opitz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-28
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 University of Utah Health Sciences Center.
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