Document Detail


Ceruletide decreases food intake in non-obese man.
MedLine Citation:
PMID:  7134028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cholecystokinin decreases food intake in animals and in man. This study investigated whether the structurally related ceruletide reduces food intake in healthy non-obese man. Twelve females and 12 males participated, after an over-night fast, in each of two experiments. During the basal 40 min, saline was infused IV. Thereafter, the infusion was, in random double blind fashion, either continued with saline or switched to 60 or 120 ng/kg b. wt/hr ceruletide. Butter was melted in a pan and scrambled eggs with ham were prepared in front of the subjects, who were instructed to eat, together with bread and mallow tea, as much as they wanted. With 120 ng/kg/hr ceruletide, the subjects ate significantly less (16.8 percent) than with saline (3725 kJ +/- 489 SEM and 4340 kJ +/- 536, respectively; p less than 0.025). They also reported less hunger (p less than 0.005) and activation (p less than 0.005) and activation (p less than 0.01), and had longer reaction times (p less than 0.01) and a weaker psychomotor performance (p less than 0.025). 60 ng/kg/hr ceruletide decreased food intake only slightly (6.6%; 3089 kJ +/- 253 and 3292 kJ +/- 300 respectively) and no significant changes in the above measures occurred. In conclusion, ceruletide reduces food intake in man, thus resembling the effects of cholecystokinin.
Authors:
G Stacher; H Steinringer; G Schmierer; C Schneider; S Winklehner
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  3     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1982 Jul-Aug
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Caerulein / adverse effects,  diagnostic use,  pharmacology*
Dose-Response Relationship, Drug
Double-Blind Method
Eating / drug effects*
Electroencephalography
Female
Humans
Hunger / drug effects
Male
Psychomotor Performance / drug effects
Reaction Time / drug effects
Chemical
Reg. No./Substance:
17650-98-5/Caerulein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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