Document Detail

Ceruletide acts in the abdomen, not in the brain, to produce satiety.
MedLine Citation:
PMID:  6099563     Owner:  NLM     Status:  MEDLINE    
Ceruletide (caerulein), a decapeptide extracted from the skin of the frog, Hyla caerulea, is very similar in structure to the C-terminal octapeptide of cholecystokinin (CCK-8). Although ceruletide and CCK-8 act through similar or identical receptors to produce the same visceral effects, previous studies in the rat suggested that peripherally administered ceruletide acted directly on the ventromedial hypothalamic (VMH) area to decrease food intake, but peripherally administered CCK-8 acted at a vagally innervated abdominal site to decrease food intake. Since it is unprecedented for these two peptides to produce the same effect by acting at different sites, we investigated the site of action of ceruletide's satiety effect in the rat and compared it to the site of action of CCK-8. The major results were: (1) intraperitoneal administration of ceruletide and CCK-8 inhibited food intake, but intraventricular administration did not; (2) the satiety effect of ceruletide and CCK-8 was not changed by bilateral lesions of the VMH; and (3) the satiety effect of ceruletide and CCK-8 was abolished or markedly reduced by bilateral abdominal vagotomy. We conclude that ceruletide acts at the same vagally innervated abdominal site to produce satiety as CCK-8 does and that neither peptide acts directly on the VMH area.
G P Smith; C Jerome; P Kulkosky; K J Simansky
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  5     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1984 Nov-Dec
Date Detail:
Created Date:  1985-05-15     Completed Date:  1985-05-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1149-57     Citation Subset:  IM    
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MeSH Terms
Abdomen / drug effects*
Brain / drug effects
Caerulein / pharmacology*
Eating / drug effects
Hypothalamus / physiology
Injections, Intraperitoneal
Injections, Intraventricular
Rats, Inbred Strains
Satiation / drug effects*
Sincalide / pharmacology
Vagus Nerve / physiology
Grant Support
Reg. No./Substance:
17650-98-5/Caerulein; 25126-32-3/Sincalide

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