Document Detail

Ceroid accumulation by murine peritoneal macrophages exposed to artificial lipid-containing particles: the role of the hydrophilic component.
MedLine Citation:
PMID:  2278824     Owner:  NLM     Status:  MEDLINE    
Murine resident peritoneal macrophages were maintained in cell culture in a medium containing 10% lipoprotein-deficient foetal calf serum to which various artificial lipid-containing particles were added. These had a core of oxidizable lipid, generally cholesteryl linoleate, and were stabilized in aqueous suspension by one of a variety of poly-L-amino acids, proteins or polysaccharides. Most particles, except those containing poly-L-lysine or poly-L-arginine (both strongly basic), were readily taken up by the macrophages to form typical ceroid inclusions, the morphological form of which was determined by the nature of the core lipid. The hydrophilic stabilizing component seemed largely irrelevant in this respect. The role of the latter appears largely to be to allow the cellular uptake of lipid, although it may also participate in ceroid formation.
K M Ardeshna; R Y Ball; K L Carpenter; J H Enright; M J Mitchinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of experimental pathology     Volume:  71     ISSN:  0959-9673     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-12     Completed Date:  1991-03-12     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  799-808     Citation Subset:  IM    
Department of Pathology, University of Cambridge, UK.
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MeSH Terms
Cells, Cultured
Ceroid / analysis,  biosynthesis*
Lipoproteins / metabolism*
Macrophages / chemistry,  metabolism*
Mice, Inbred Strains
Peptides / metabolism
Polysaccharides / metabolism
Time Factors
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Ceroid; 0/Lipoproteins; 0/Peptides; 0/Polysaccharides

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