| Ceroid accumulation by murine peritoneal macrophages exposed to artificial lipid-containing particles: the role of the hydrophilic component. | |
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MedLine Citation:
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PMID: 2278824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Murine resident peritoneal macrophages were maintained in cell culture in a medium containing 10% lipoprotein-deficient foetal calf serum to which various artificial lipid-containing particles were added. These had a core of oxidizable lipid, generally cholesteryl linoleate, and were stabilized in aqueous suspension by one of a variety of poly-L-amino acids, proteins or polysaccharides. Most particles, except those containing poly-L-lysine or poly-L-arginine (both strongly basic), were readily taken up by the macrophages to form typical ceroid inclusions, the morphological form of which was determined by the nature of the core lipid. The hydrophilic stabilizing component seemed largely irrelevant in this respect. The role of the latter appears largely to be to allow the cellular uptake of lipid, although it may also participate in ceroid formation. |
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Authors:
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K M Ardeshna; R Y Ball; K L Carpenter; J H Enright; M J Mitchinson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of experimental pathology Volume: 71 ISSN: 0959-9673 ISO Abbreviation: Int J Exp Pathol Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-03-12 Completed Date: 1991-03-12 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 9014042 Medline TA: Int J Exp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 799-808 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Ceroid / analysis, biosynthesis* Lipoproteins / metabolism* Macrophages / chemistry, metabolism* Male Mice Mice, Inbred Strains Peptides / metabolism Polysaccharides / metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Ceroid; 0/Lipoproteins; 0/Peptides; 0/Polysaccharides |
| Comments/Corrections | |
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