Document Detail

Cerium caused life span shortening and oxidative stress resistance in Drosophila melanogaster.
MedLine Citation:
PMID:  19828196     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of the rare earth element cerium (Ce) on the life span and biomarkers of oxidative stress in the fruit fly (Drosophila melanogaster). Fruit flies were fed on media with different dose of ceric sulfate (1, 4, 16, 64, 256, 1024mg/L, corresponding to cerium concentrations of 0.45, 1.65, 6.91, 26.3, 104, and 429microg/g culture medium). Mean life span, maximum life span, and fertility were calculated. There was a significant decrease in mean life span and maximum life span with increasing doses of cerium. At some concentrations, there was a decrease in reproductive output, especially concentrations >6.91microg/g. We also measured superoxide dismutase (SOD) activity, catalase (CAT) activity, and lipid peroxidation product levels (malondialdehyde (MDA) content). Cerium caused a significant increase in MDA content and decrease in SOD and CAT activities at concentrations >6.91microg/g. These results suggest that cerium may result in oxidative toxicity to D. melanogaster.
Shu-Feng Huang; Zong-Yun Li; Xiu-Qin Wang; Qiu-Xiang Wang; Fang-Fang Hu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-13
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  73     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-11-10     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Institute of Cellular and Molecular Biology, School of Life Science, Xuzhou Normal University, Xuzhou, Jiangsu 221116, PR China.
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MeSH Terms
Catalase / metabolism
Cerium / toxicity*
Dose-Response Relationship, Drug
Drosophila melanogaster / drug effects*,  metabolism
Fertility / drug effects
Longevity / drug effects*
Malondialdehyde / analysis
Oxidative Stress / drug effects*
Superoxide Dismutase / metabolism
Reg. No./Substance:
542-78-9/Malondialdehyde; 7440-45-1/Cerium; EC; EC Dismutase

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