Document Detail


Cerenkov emission induced by external beam radiation stimulates molecular fluorescence.
MedLine Citation:
PMID:  21859013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Cerenkov emission is induced when a charged particle moves faster than the speed of light in a given medium. Both x-ray photons and electrons produce optical Cerenkov photons in everyday radiation therapy of tissue; yet, this phenomenon has never been fully documented. This study quantifies the emissions and also demonstrates that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms.
METHODS: In this study, Cerenkov emission induced by radiation from a clinical linear accelerator is investigated. Biological mimicking phantoms were irradiated with x-ray photons, with energies of 6 or 18 MV, or electrons at energies 6, 9, 12, 15, or 18 MeV. The Cerenkov emission and the induced molecular fluorescence were detected by a camera or a spectrometer equipped with a fiber optic cable.
RESULTS: It is shown that both x-ray photons and electrons, at MeV energies, produce optical Cerenkov photons in tissue mimicking media. Furthermore, we demonstrate that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms.
CONCLUSIONS: The results here indicate that molecular fluorescence monitoring during external beam radiotherapy is possible.
Authors:
Johan Axelsson; Scott C Davis; David J Gladstone; Brian W Pogue
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medical physics     Volume:  38     ISSN:  0094-2405     ISO Abbreviation:  Med Phys     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-08-23     Completed Date:  2011-10-05     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0425746     Medline TA:  Med Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4127-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Fluorescence
Luminescent Measurements / methods*
Molecular Probe Techniques*
Radiation Dosage
Radiometry / methods*
Radiotherapy, Conformal / methods*
Grant Support
ID/Acronym/Agency:
P01 CA084203/CA/NCI NIH HHS; P01CA084203/CA/NCI NIH HHS; P30 CA023108/CA/NCI NIH HHS; R01 CA078734/CA/NCI NIH HHS; R01 CA109558/CA/NCI NIH HHS; R01 CA120368/CA/NCI NIH HHS; R01CA120368/CA/NCI NIH HHS
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