| Cerenkov emission induced by external beam radiation stimulates molecular fluorescence. | |
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MedLine Citation:
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PMID: 21859013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Cerenkov emission is induced when a charged particle moves faster than the speed of light in a given medium. Both x-ray photons and electrons produce optical Cerenkov photons in everyday radiation therapy of tissue; yet, this phenomenon has never been fully documented. This study quantifies the emissions and also demonstrates that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms. METHODS: In this study, Cerenkov emission induced by radiation from a clinical linear accelerator is investigated. Biological mimicking phantoms were irradiated with x-ray photons, with energies of 6 or 18 MV, or electrons at energies 6, 9, 12, 15, or 18 MeV. The Cerenkov emission and the induced molecular fluorescence were detected by a camera or a spectrometer equipped with a fiber optic cable. RESULTS: It is shown that both x-ray photons and electrons, at MeV energies, produce optical Cerenkov photons in tissue mimicking media. Furthermore, we demonstrate that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms. CONCLUSIONS: The results here indicate that molecular fluorescence monitoring during external beam radiotherapy is possible. |
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Authors:
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Johan Axelsson; Scott C Davis; David J Gladstone; Brian W Pogue |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Medical physics Volume: 38 ISSN: 0094-2405 ISO Abbreviation: Med Phys Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-08-23 Completed Date: 2011-10-05 Revised Date: 2013-06-13 |
Medline Journal Info:
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Nlm Unique ID: 0425746 Medline TA: Med Phys Country: United States |
Other Details:
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Languages: eng Pagination: 4127-32 Citation Subset: IM |
Affiliation:
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Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA. johan.axelsson@dartmouth.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Fluorescence Luminescent Measurements / methods* Molecular Probe Techniques* Radiation Dosage Radiometry / methods* Radiotherapy, Conformal / methods* |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA084203/CA/NCI NIH HHS; P01CA084203/CA/NCI NIH HHS; R01 CA078734/CA/NCI NIH HHS; R01 CA078734-03/CA/NCI NIH HHS; R01 CA109558/CA/NCI NIH HHS; R01 CA120368/CA/NCI NIH HHS; R01CA120368/CA/NCI NIH HHS |
| Comments/Corrections | |
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