Document Detail


Cerebrovascular resistance in ischemia.
MedLine Citation:
PMID:  6782547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cerebrovascular resistance (CVR) of rat, and its dependence on stagnant blood or endothelial capillary swelling, was studied after 10 min of total ischemia by 10 s single carotid infusion of [14C]butanol in saline. The regional saline flow (CPR) was calculated from the uptake of [14 C]butanol. CVR was estimated at infusion pressures ranging from 8--25 kPa (60--190 mm Hg). At 14.7 kPa (110 mm Hg) infusion pressure, the regional CVR of the non-ischemic group varied between 0.21 and 0.40 kPa 100 g min ml-1. After 10 min of complete global cerebral ischemia, it increased to values between 0.82 and 1.95. Removal of blood from the brain by rinsing prior to ischemia did not change the CVR in ischemia. Increasing the plasma osmolality by 8% with mannitol before ischemia attenuated the CVR increase in ischemia. Thus, although osmotic swelling of endothelial cells contributed, the main cause of the CVR increase in ischemia was constriction of arterioles.
Authors:
E Siemkowicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  388     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  243-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / blood supply
Capillaries / physiopathology
Capillary Resistance / drug effects
Ischemic Attack, Transient / physiopathology*
Male
Mannitol / pharmacology
Mathematics
Rats
Vascular Resistance* / drug effects
Chemical
Reg. No./Substance:
69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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