Document Detail


Cerebrovascular permeability in acute hypertension: effect of flunarizine.
MedLine Citation:
PMID:  2089934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pattern of Evans blue extravasation in the brain in norepinephrine-induced acute hypertension is similar to our previous observations using horseradish peroxidase as a tracer. Pretreatment with flunarizine IV resulted in significant reduction of RISA leakage in all regions of the brains of acutely hypertensive rats. The reduction in RISA leakage in the drug-treated hypertensive group is not attributable to differences in the blood pressure elevations which were not significantly different in both groups. These studies suggest a role for calcium in the increased endothelial permeability occurring in cerebral vessels in acute hypertension. Further morphological studies are required to determine whether flunarizine reduces permeability by decreasing pinocytosis.
Authors:
S Nag; L Young
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurochirurgica. Supplementum     Volume:  51     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir Suppl (Wien)     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-24     Completed Date:  1991-05-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0140560     Medline TA:  Acta Neurochir Suppl (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  344-5     Citation Subset:  IM    
Affiliation:
Department of Pathology (Neuropathology), Queen's University, Kingston, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Capillary Permeability* / drug effects
Cerebrovascular Circulation / drug effects*
Evans Blue / diagnostic use
Flunarizine / pharmacology*
Hypertension / metabolism,  physiopathology*
Iodine Radioisotopes / diagnostic use
Rats
Rats, Inbred WF
Serum Albumin / metabolism
Serum Albumin, Radio-Iodinated / diagnostic use
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Serum Albumin; 0/Serum Albumin, Radio-Iodinated; 314-13-6/Evans Blue; 52468-60-7/Flunarizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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