Document Detail

Cerebrovascular manifestations of Takayasu arteritis in Europe.
MedLine Citation:
PMID:  15840603     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Takayasu arteritis is well known as a cause of stroke in Asia but has rarely been described in the Western world. Here we report the clinical and neuroimaging follow-up of a series of patients with Takayasu arteritis from Europe. METHODS: Seventeen consecutive patients who fulfilled the diagnostic criteria for Takayasu arteritis of the American College of Rheumatology were evaluated on follow-up by standardized neurological examination, sonography and MRI. RESULTS: At follow-up almost 20 yr after onset of symptoms, the subclavian artery and the common carotid artery were often affected. In addition, evidence of intracranial pathology was found in seven patients. In contrast to the severe vessel involvement, the neurological state was stable. Two patients had suffered from stroke before the diagnosis was made and therapy was initiated, and one patient had recurrent transient ischaemic attacks. Intermittent dizziness was associated with pathology of the vertebral and basilar arteries. However, clinical symptoms of subclavian steal syndrome were rare. CONCLUSION: This case series shows that the clinical neurological course of Takayasu arteritis on treatment is benign in most cases despite the severe vascular involvement.
P A Ringleb; E I Strittmatter; M Loewer; M Hartmann; J B Fiebach; C Lichy; R Weber; C Jacobi; K Amendt; M Schwaninger
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Publication Detail:
Type:  Journal Article     Date:  2005-04-19
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  44     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-21     Completed Date:  2005-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1012-5     Citation Subset:  AIM; IM    
Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
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MeSH Terms
Carotid Artery, Common / pathology*,  ultrasonography
European Continental Ancestry Group*
Follow-Up Studies
Ischemic Attack, Transient / etiology
Magnetic Resonance Imaging
Middle Aged
Stroke / etiology
Subclavian Artery / pathology*,  ultrasonography
Takayasu Arteritis / complications,  ethnology*,  pathology
Ultrasonography, Doppler

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